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«1 Michael N Shadlen CURRICULUM VITAE FIELD OF SPECIALIZATION: I am a neuroscientist and a neurologist with an abiding interest in fundamental, basic, ...»

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1

Michael N Shadlen

CURRICULUM VITAE

FIELD OF SPECIALIZATION:

I am a neuroscientist and a neurologist with an abiding interest in fundamental, basic,

neuroscience of vision and cognition. I have been studying the neurobiology of decision

making for over 20 years, and I have made fundamental contributions to this field by

combining behavior, electrophysiology and computational methods. My research serves to elucidate the neural mechanisms that support normal cognitive operations that underlie inference from evidence, the tradeoff between the speed and accuracy of a decision, the assignment of confidence or certainty to a decision, and the capacity to combine and weigh evidence of varying degrees of reliability. These and other insights provide a window on wider aspects of higher brain function, such as reasoning, planning, strategizing and vacillating. I predict that the mechanisms we study in normal brains will constitute important failure modes that underlie a variety of cognitive disorders—despite the great diversity of their ultimate etiologies. I believe we will one day manipulate and restore these basic mechanisms to treat brain disorders affecting cognition. Thus, my research will ultimately help patients with disorders of higher cognitive functions affecting personality, ideation, volition, awareness and decision making.

OFFICE ADDRESS:

Department of Neuroscience Columbia University Medical Center College of Physicians and Surgeons 630 West 168th Street New York, NY 10032 212-305-9941 shadlen@columbia.edu

ACADEMIC TRAINING:

1981 Brown University, B.A., Biology 1985 University of California, Berkeley, Ph.D., Neurobiology “Neural Mechanisms of Stereoscopic Depth Perception” Thesis Sponsor: Dr. Ralph D. Freeman 1988 Brown University, M.D.

07/88-06/89 Internship, Medicine, Kaiser Permanente Medical Center 07/89-06/92 Residency, Neurology, Stanford Medical School 08/85-06/86 Postdoc, University of California, Berkeley Vision Sciences, Laboratory of Dr. Ralph D. Freeman 07/93-08/96 Postdoc, Stanford Medical School Neurophysiology, Laboratory of Dr. William T. Newsome

ACCADEMIC APPOINTMENTS:

1991-1992 Chief Resident in Neurology- Stanford University, Stanford, CA 1993-1995 Clinical Instructor of Neurology- Stanford University, Stanford, CA 1995-2012 Core Staff Scientist- Primate Research Center, University of Washington Seattle, WA 2 Michael N Shadlen 1995-2001 Assistant Professor- Department of Physiology and Biophysics, University of Washington, Seattle, WA 1997-2001 Adjunct Assistant Professor- Department of Neurology, University of Washington, Seattle, WA 2000- Investigator, Howard Hughes Medical Institute 2001-2005 Associate Professor- Department of Physiology and Biophysics, University of Washington, Seattle, WA 2001-2005 Adjunct Associate Professor- Department of Neurology, University of Washington, Seattle, WA 2002-2007 Co-Director, Graduate Program- Department of Neurobiology, University of Washington, Seattle, WA 2005-2012 Professor- Department of Physiology and Biophysics, University of Washington, Seattle, WA 2005-2012 Adjunct Professor- Department of Neurology, University of Washington, Seattle, WA 2012- Affiliate Professor- Department of Physiology and Biophysics, University of Washington, Seattle, WA 2012- Professor- Department of Neuroscience, Columbia University, NY, NY

PROFESSIONAL ORGANIZATIONS AND SOCIETIES (all active):

American Academy of Neurology Society for Neuroscience Association for Research in Vision and Ophthalmology American Association for the Advancement of Science Society for the Neural Control of Movement Vision Sciences Society Northwest Association for Biomedical Research American Physiological Society The Neuroscience Research Program Neuroethics Society Dana Foundation Kavli Institute for Brain Science Association for Psychological Sciences - Fellow International Neuropsychological Society Institute of Medicine (IOM) of the National Academies

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“Course leader” also includes lectures; “Instructor” implies a lecture module of 1-3 weeks (typically 2); “Lectures” implies 2 or more lectures and discussions, whereas “Lecture” implies one guest lecture. NB = Graduate Program in Neurobiology & Behavior; PBIO = Department of Physiology & Biophysics.

–  –  –

2003-2009 Journal of Vision (reviewing editor) 2003-2011 Trends in Neuroscience 2004-2009 Journal of Neuroscience 2005-present Cerebral Cortex 2008-present Current Biology 2011-present Neuroscience Bulletin 2015-present Current Opinion in Neurobiology

DEPARTMENT AND UNIVERSITY COMMITTEES:

1997-2012 Search Committee, Associate Director, University of Washington Regional Primate Research Center 1998-1999 Search Committee, Neurosciences Systems Appointment University of Washington, Department of Physiology and Biophysics 1997-2001 Faculty Lecture Series Committee, University of Washington, Department of Physiology and Biophysics 1999-2012 Chair, Search Committee, University of Washington, Department of Physiology and Biophysics 2001-2007 Co-Director, Graduate Program in Neurobiology and Behavior 2002-2012 Chair, Search Committee, Computational Neuroscience, Department of Physiology and Biophysics 2002-2012 Lamport Lecture Selection Committee, Hille Lecturer Selection Committee 2003 Search Committee, Systems Neuroscience, Molecular Physiology and Biophysics 2004-2012 Search Committee, Primate Neuroscience, Departments of Physiology and Biophysics, Biological Structure and Washington National Primate Research Center 2005-2007 Chair, Graduate and Joint/Affiliate Faculty Nominations Committee, Department of Physiology and Biophysics 2009-2012 Selection Committee, Wayne Crill Award 2008-2012 Promotions Committees (2) 2010 Committee on Recruitment of Under Represented Minority Students 2012- Steering Committee, Grossman Center for the Statistics of Mind, Columbia University Medical Center 2012- Search Committee, Director of Neuroimaging, Columbia University 2012- Search Committee, Department of Neuroscience, Columbia University Medical Center 2014- Presidential Scholars in Society and Neuroscience Advisory Committee 2015 Search Committee, Institute for Comparative Medicine (ICM), Columbia University Medical Center

–  –  –





Department of Engineering and Biostructure, University of Washington:

1998-2001 David Bailey

Department of Applied Mathematics, University of Washington:

2009-2012 Nicholas Cain

Department of Neurobiology, Baylor College of Medicine (external):

2008-2012 James Cotton

Department of Biomedical Engineering, Columbia University:

2013-present Bin Lou

Department of Neuroscience, Columbia University:

2013-present Martin Vignovich 2013-present Scott Bolkan 2014-present Jalal Baruni

–  –  –

GRANTS AND CONTRACTS:

Current awards HOWARD HUGHES MEDICAL INSTITUTE, 2000-present Supports all research and laboratory infrastructure. The HHMI does not identify specific aims. All aims of the awards below are supported by HHMI, and the budgets of these grants are small, thanks to HHMI support.

NEURAL MECHANISMS OF VISUAL PERCEPTION, NIH R01EY11378, 1996present.

M. Shadlen (PI) The major goals of this project are to study the mechanisms that underlie formation of a decision about a visual stimulus. The experiments investigate response properties of single neurons during performance of a motion discrimination task near psychophysical threshold. Our current emphasis is on the extension of the mechanisms we have discovered in simple 2-choice tasks to more complex settings: more options, more complex inference.

HOW EPISODIC MEMORY GUIES DECISIOS: NEURAL MECHANISMS AND

IMPLICATIONS FOR MEMORY LOSS, THE McKNIGHT ENDOWMENT FUND

FOR NEUROSCIENCE, 2016-2019.

D. Shomany (PI). M. Shadlen (Consultant) The grant aims to test how memories are sampled to guide value-based decisions, using a combination of functional MRI, behavior, and computational modeling in healthy human participants and in patients with memory impairments.

Past awards

DECIDING AND REVISING: A UNIFYING FRAMEWORKD FOR DECISION

MAKING AND MOTOR CONTROL, INTERNATIONAL HUMAN FRONTIERS

RESEARCH PROGRAM, 2011-2015 M. Shadlen (co-PI). D. Wolpert (PI) This is a collaborative proposal to formulate and test experimentally principles common to decision-making and the optimal control of limb movement. These principles include the tradeoff between speed and accuracy, sampling cost and revision of an action or choice after initiation.

–  –  –

NEURAL BASIS OF BAYESIAN INFERENCE AND DECISION MAKING, JAMES

S. McDONNELL FOUNDATION, 2006-2011.

M. Shadlen (PI) A. Pouget (co-PI) The major goal of this project is to develop theoretical tools to study probabilistic population codes in a variety of contexts.

CRCNS: BAYESIAN DECISION MAKING WITH PROBABILISTIC POPULATION

CODES, NIH R01DA022780, 2007-2010.

M. Shadlen (PI). A. Pouget (co-PI) Collaborative Research in Computational Neuroscience (CRCNS). The project examines the role of probabilistic population encoding by neurons in the parietal cortex.

TEMPORAL INTEGRATION AND WORKING MEMORY, THE McKNIGHT

ENDOWMENT FUND FOR NEUROSCIENCE, 1996-1999 M. Shadlen (PI) Inactive. This project established a connection between frontal lobe mechanisms supporting working (short-term) memory and decision making.

PUBLICATIONS:

1. van den Berg R, Anandalingam K, Zylberberg A, Kiani R, Shadlen MN, Wolpert DM (2016) A common mechanism underlies changes of mind about decisions and confidene. eLife. In Press

2. Jazayeri M, Shadlen MN (2015) A neural mechanism for sensing and reproducing a time interval. Curr Biol. PMCID: PMC4618078

3. Finnerty, G. T., Shadlen, M. N., Jazayeri, M., Nobre, A. C., & Buonomano, D. V.

(2015) Time in Cortical Circuits. The Journal of Neuroscience: the Official

Journal of the Society for Neuroscience, 35(41), 13912–13916. PMCID:

PMC4604229

4. de Lafuente V, Jazayeri M, Shadlen MN (2015) Representation of accumulating

evidence for a decision in two parietal areas. J Neurosci 35:4306-4318 PMCID:

PMC4355201

5. Kira S, Yang T, Shadlen MN (2015) A neural implementation of Wald's sequential probability ratio test. Neuron 85:861-873 PMCID: PMC4365451

6. Kiani R, Corthell L, Shadlen MN (2014) Choice certainty is informed by both evidence and decision time. Neuron 84:1329-1342. PMCID: PMC4271191

7. Hanks T, Kiani R, Shadlen MN (2014) A neural mechanism of speed-accuracy tradeoff in macaque area LIP. eLife:e02260. PMCID: PMC4054775

8. Fetsch CR, Kiani R, Newsome WT, Shadlen MN (2014) Effects of cortical microstimulation on confidence in a perceptual decision. Neuron 83:797-804.

PMCID: PMC4141901

9. Burk D, Ingram JN, Franklin DW, Shadlen MN, Wolpert DM (2014) Motor effort alters changes of mind in sensorimotor decision making. PLoS ONE 9:e92681.

PMCID: PMC3961398

10. Kiani R, Churchland AK, Shadlen MN (2013) Integration of direction cues is 10 Michael N Shadlen invariant to the temporal gap between them. J Neuroscience 33:16483-16489.

PMCID: PMC3797371

11. Cain N, Barreiro A, Shea-Brown E, Shadlen MN (2013) Neural integrators for decision making: A favorable tradeoff between robustness and sensitivity. J Neurophysiol PMCID: PM3653050

12. Huang Y, Friesen AL, Hanks TD, Shadlen MN, Rao RPN (2012) How prior

probability influences decision making: A unifying probabilistic model. In:

Advances in Neural Information Processing Systems: MIT Press.

13. Shadlen MN, Roskies AL (2012) The neurobiology of decision-making and responsibility: reconciling mechanism and mindedness. Front Neurosci 6:56.1-12.

PMCID: PMC3332233

14. Drugowitsch J, Moreno-Bote R, Churchland AK, Shadlen MN, Pouget A (2012) The cost of accumulating evidence in perceptual decision making. J Neurosci 32:3612-3628. PMCID: PMC3329788

15. Selen LP, Shadlen MN, Wolpert DM (2012) Deliberation in the motor system:

reflex gains track evolving evidence leading to a decision. J Neurosci 32:2276PMCID: PMC3299561

16. Hedges JH, Gartshteyn Y, Kohn A, Rust NC, Shadlen MN, Newsome WT, Movshon JA (2011) Dissociation of neuronal and psychophysical responses to local and global motion. Curr Biol 21:2023–2028. PMCID: PMC3241977

17. Hanks TD, Kiani R, Mazurek M, Hopp E, Shadlen MN (2011) Elapsed decision time affects the weighting of prior probability in a perceptual decision task. J Neurosci 31:6339-52. PMCID: PMC3356114

18. Churchland AK, Kiani R, Chaudhuri R, Wang XJ, Pouget A, Shadlen MN (2011)

Variance as a signature of neural computations during decision-making. Neuron:

69:818-31. PMCID: PMC3066020

19. Jazayeri M, Shadlen MN (2010). Temporal context calibrates interval timing.

Nature Neurosci 13:1020-6. PMCID: PMC2916084

20. Resulaj A, Kiani R, Wolpert DM, Shadlen MN (2009) Changes of Mind in Decision-Making. Nature 461:263-266. PMCID: PMC2875179

21. Kiani R, Shadlen MN (2009) Representation of confidence associated with a

decision by neurons in the parietal cortex. Science 324:759-764. PMCID:

PMC2738936

22. Kiani R, Hanks TD, Shadlen MN (2008) Bounded integration in parietal cortex underlies decisions even when viewing duration is dictated by the environment. J Neurosci 28:3017-3029. PMID: 18354005

23. Ganguli S, Bisley JW, Roitman JD, Shadlen MN, Goldberg ME, Miller KD (2008) One-dimensional dynamics of attention and decision making in LIP.

Neuron 58:15-25. PMID: 18400159

24. Churchland AK, Kiani R, Shadlen MN (2008) Decision-making with multiple alternatives. Nat Neurosci 11:693-702. PMCID: PMC2453226



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