FREE ELECTRONIC LIBRARY - Dissertations, online materials

Pages:   || 2 | 3 | 4 | 5 |   ...   | 9 |

«Program Feb 21 (Fri).. 08 Feb 22 (Sat).. 10 Feb 23 (Sun).. 12 Abstract Feb 21 (Fri).. 15 Feb 22 (Sat).. 59 Feb 23 (Sun).. 79 Acknowledgements ...»

-- [ Page 1 ] --


Table of Contents

Introduction ………………………………………………………………………… 05

Information ………………………………………………………………………… 07


Feb 21 (Fri) …………………………………………………………… 08

Feb 22 (Sat) …………………………………………………………… 10

Feb 23 (Sun) …………………………………………………………… 12 Abstract Feb 21 (Fri) …………………………………………………………… 15 Feb 22 (Sat) …………………………………………………………… 59 Feb 23 (Sun) …………………………………………………………… 79 Acknowledgements …………………………………………………………… 103



-5- Takamatsu Parkinson Disease Foundation President Mitsutoshi Yamamoto, MD, PhD Director, Takamatsu Neurology Clinic President, Takamatsu Parkinson Disease Foundation Co-President Nobutaka Hattori, MD, PhD Professor of Neurology Department of Neurology Juntendo University International Advisory Board David J Burn Newcastle upon Tyne Werner Poewe Innsburck Olivier Rascol Toulous Heinz Reichmann Dresden Anthony Schapira London EK Tan Singapore Louis Tan Singapore Eduardo Tolosa Barcelona Genjiro Hirose Kanazawa Shigeki Kuzuhara Mie Eldad Melamed Tel-Aviv Yoshikuni Mizuno Tokyo Ruey-Meei Wu Taipei The local organizing committee Chair Mitsutoshi Yamamoto Co-Chair Nobutaka Hattori Member Kazuko Hasegawa Kenichi kashihara Seiji Kikuchi Jun-ichi Kira Sadako kuno Yasuyuki Okuma Norihiro Suzuki Ryousuke Takahashi Atsushi Takeda Hidehiro Mizusawa Miho Murata Hirohisa Watanabe Fumihito Yoshii Yoshio Tsuboi Operating committee Chair Hirohisa Watanabe Member Masaaki Hirayama Tadashi Ichikawa Katsuo Kimura Ryouichi Kurisaki Tetsuya Maeda Suguru Nishida Hidemoto Saiki Kazuto Yoshida

-6- Information Registration Information Registration: on-site only available Pre-registration is appreciated.

No discount for pre-registration is available

Registration Times:

Feb 21(Fri) 08:20-18:40 Feb 22(Sat) 08:30-17:30 Feb 23(Sun) 08:30-15:40

Registration Fee:

Until January31 Until February10 Onsite Medical student free free 3,000 Trainee/Co-medical 5,000 6,000 7,000 Neurologist 15,00020,000 25,000

–  –  –

Notice to Speaker and Chair (presentation material) Your presentation can be pre-checked and accepted in PC desk located in 6th floor on conference hall.

Internet Service A wireless internet service is available.

Official Language is English (Day1,2) Social event Reception: 18:30-20:30 free of charge on Feb. 21, 2014 “Mykeila” near congress venue 5 minutes walk Symposium dinner: 20:00-22:00 at Japanese restaurant Ryoutei “ Ni-cho” Seats is still available (¥10,000JPY) Notice Recoding and Photos are strictly prohibited.

The eating and drinking in the hall is prohibited.

(Only the PET bottle can be brought in.)

–  –  –

13:00-13:30 Lunch Chair Ruey-Meei Wu & R.Bhidayasiri 13:30-14:00 FTD and parkinsonism Ruey-Meei Wu 14:00-14:30 Drug-induced parkinsonism E.Melamed

–  –  –

Luncheon seminar 共催:日本ベーリンガーインゲルハイム Chair D.Burn 12:30-13:30 Hyposmia and cholinergic deficiency in A.Takeda Parkinson Disease

–  –  –

10:00-10:30 coffee break Chair H.Tachibana & S.Orimo 10:30-11:00 Rehabilitation in PD from walking to T.Ichikawa speech : the state of the art 11:00-11:30 Excersie and cognition in PD and AD R.Kurisaki

–  –  –

What is Atypical Parkinsonism?

Werner Poewe Dept of Neurology, Innsbruck Medical University The term ‚Atypical Parkinsonism’ is being used to describe a heterogeneousgroup of neurodegenerative conditions, where the clinical motor syndrome of parkinsonism is associated with additional clinical features not typically seen in ‚classical’ idiopathic Parkinson’s Disease (PD). The textbook listings of the atypical parkinsonian disorders usually include the Multiple System Atrophy (MSA) and Dementia with Lewy Bodies (DLB) which – like PD – are associated with synuclein pathology, as well as Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD), where tau-positive neuronal inclusions are the pathological hallmark. The clinical qualifyer of ‚atypical’ features, however, maybe imperfect for several reasons: first, some ‚atypical’ features used to distinguish these conditions from PD may also occur in post-mortem confirmed PD – including early severe dementia, autonomic dysfunction, dystonia and poor Levodopa response (Hughes et al., Brain, 2002). Second, some patients suffering from one of these types of ‚atypical parkinsonism’ may not show any of the defining atypical features. This is best exemplified by the parkinsonian variants of MSA or PSP which can be associated with a sustained meaningful response to Levodopa. In addition, PSP-P patients may show classical rest tremor and a rather benign course of disease progression with absence of early falls and supranuclear gaze palsy,mimicking the clinical signature of PD. Likewise, MSA-P patients may present with asymmetric or even unilateral parkinsonism without significant autonomic dysfunction. These typical-PD-look-alike presentations are the prime source of diagnostic difficulty in atypical parkinsonism. Finally, DLB in particular does not have any features which in themselves are at all ‚atypical’ for PD. In fact, everything listed in the

- 16 clinical diagnostic criteria is also a classical symptom in PD dementia, such that the only clinical anchor of DLB is the timing of dementia diagnosis relative to the diagnosis of parkinsonism (i.e. the ‚one-year-rule’).

Nevertheless, classifying certain features, drug-responses and modes of progression as ‚atypical’ for PD is highly useful for alerting clinicians to consider or reconsider initial diagnostic classifications and to plan diagnostic work-up. Misclassifications of patients with degenerative parkinsonian disorders will, however, continue to occur – particularly in early disease stages - until there are sensitive and specific biomarkers enabling secure discrimination between these conditions.

–  –  –

The definition of Parkinson Disease Eduardo Tolosa, MD Parkinson disease definition: An insidious unilateral onset of bradykinesia, rigidity and rest tremor between ages of 30 and 85 years. Mild male preponderance,no more than one affected first degree relative. Spread to involve other side within 3 years, but disability remains asymmetrical throughout. Good sustained response to l-dopa with eventual emergence of psychomotor fluctuations and dyskinesias. Increasing gait, balance and speech problems after 5 years disease Death on average 14 years after diagnosis (may be over 30 years in young-onset cases).

Whether presence of Lewy bodies in the central nervous system or the presence of certain non motor symptoms are part of the definition of Parkinson disease is a matter of debate which I will discuss in my presentation.

- 18 Bioskech Prof. Eduardo Tolosa MD, FRCP February 2014 Eduardo Tolosa obtained his MD degree from the University of Barcelona and received his neurological training at the University of Minnesota Hospital in Minneapolis. He is Professor of Neurology at the University of Barcelona and Director of the Parkinson Disease Research Program at the University of Barcelona Hospital. He is a founding member and past president of the Movement Disorder Society. He is also past president of the European Neurological Society. Prof. Tolosa was certified as a neurologist by the American Board of Neurology and Psychiatry and is currently a Fellow of the American Academy of Neurology, the American Neurological Association and the Royal College of Physicians. He is the recipient of the American Academy of Neurology 2014 Movement Disorders Research Award.

Professor Tolosa’s research interests are in movement disorders and particularly in issues related to experimental therapeutics, etiology and pathophysiology of various Parkinson syndromes. In the area of experimental therapeutics, he was involved in pioneering studies defining mechanisms underlying levodopa-related motor fluctuations, and his team has been among the first in Europe to evaluate the efficacy of novel surgical strategies for Parkinson’s disease, such as subthalamic nucleus stimulation, subcutaneous dopamine agonist infusions and intraduodenal infusions of levodopa.

Other areas of current research include assessment of non-motor symptoms in asymptomatic carriers of Parkinson-associated genetic mutations and the role of neuroimaging in early detection of Parkinson disease.

–  –  –

Aging and Parkinson’s disease Heinz Reichmann, MD, PhD, FRCP, FAAN Director of Department of Neurology, Technische Universitaet Dresden, Fetscherstrasse 74, D-01307 Dresden Heinz.Reichmann@mailbox.tu-dresden.de The most important risk factor for the development of Parkinson’s disease (PS) is aging.

With increasing age, more and more individuals develop a Parkinson syndrome. Thus, the question arises whether PS is an abnormal aging process of the brain. Until now, most neuroscientists claim that the cellular mechanisms which are responsible for ageing of midbrain dopaminergic neurons, are not related to those which cause dopamine neuron degeneration in Parkinson’s disease (PD). In contrast, other studies in non-human primates suggest that ageing induces a pre-parkinsonian state and that the degeneration of dopaminergic neurons in PD patients is only an accelerated form of ageing; they imply that all of us would suffer from PD if we only lived long enough.

There is also increasing evidence that there are more than 30 gene constellations which put an individuum at risk of developing PD.

Several mechanisms of accelerated cell death have been described so far, in particular RNA oxidation is more frequently observed in vulnerable neurons at an early-stage of age-related neurodegenerative disease. In contrast to normal ageing, PD patients show more alpha-synuclein accumulation in the basal ganglia and in other regions of the central and enteric nervous system. Interestingly, alpha-synuclein accumulation is infrequently seen in normal ageing brain. Some people assume that in PD patients there may be insufficient compensatory mechanisms in vulnerable brain regions, which discriminates patients with the full picture of PD from those with only Parkinsonian features such as slow gait.

Clinically, there are several interesting features which might help to distinguish normal ageing from PD. The rate of progression of white matter hyperintensities is slower in the MRI of normal old individuals compared to those with PD. Whilst the annual decrease in striatal dopamine receptor binding is approximately 0.5% in normal old

- 20 people, it is much higher (5%) in patients with PD.

Life expectancy of PD patients is only mildly reduced compared to an age-related control group. Clinically, it is rather intriguing that the decline in olfaction is faster in PD than in normal ageing. This observation correlates well with the abundance of alpha-synuclein in the olfactory bulb of normal people and patients with PD. There is a strong correlation between hyposmia or anosmia and the development of PD. There is also a significant difference, when non-motor symptoms which occur in most PD patients, are compared to age-matched controls. Non-motor symptoms are very common both in the healthy elderly and in PD patients. A significantly higher prevalence of non-motor symptoms (sexual function, perceptual problems/hallucinations, fatigue and mood changes) is observed in PD patients.

Since PD is a movement disorder and physical mobility is reduced in the elderly, it is also of interest that PD patients present with step length asymmetry and increased co-activation of agonists and antagonists when walking or performing arm motor skills.

This might also indicate that patients with PD lack compensatory mechanisms in their motor and pre-motor cortex which are still available to age-matched controls.

A large body of literature covers neuropsychological differences between normal old people and PD patients. For example, PD patients are less able to learn new tasks.

Impairments of word identification, of the number of words used and other speech abnormalities are well documented. Decision-making and executive functions (Wisconsin card sorting test) are major problems in PD patients. It is rather interesting that the theory of mind is highly impaired in PD patients which might also contribute to their social isolation in late stages of the disease. Although both controls and PD patients prefer familiar tasks to new ones, PD patients do so even more. There is also good evidence that PD has a major impact on error processing.

In conclusion, these selected examples confirm that there is a major and significant difference between normal aging and PD.

- 21 Heinz Reichmann, MD, PhD, FRCP, FAAN – biosketch Heinz Reichmann MD PhD graduated from the University of Freiburg, Germany in

1979. He spent the following four years as a research fellow at the Institute for Biochemistry, University of Konstanz, Germany and the Institute of Neurology, Columbia University, USA. This was paid for by honorary grants for excellency to Dr.

Reichmann. He returned to Germany where he held a number of positions at the University of Würzburg, becoming Professor of Neurology in 1990. In 1996, he was appointed Chairmann of the Department of Neurology at the University of Dresden, where he is now also Dean of the Medical Faculty.

Pages:   || 2 | 3 | 4 | 5 |   ...   | 9 |

Similar works:

«Conflict Resolution in Colombia Pat Paterson William J. Perry Center for Hemispheric Defense Studies Perry Center Occasional Paper June 2013 Foreword When, in August 2012, Colombian President Juan Manuel Santos announced peace talks with the FARC leadership, the overall reaction was a mix of surprise and skepticism. Many were surprised because Santos agreed to sit with the FARC when everything indicated that the government was finally winning the 50-year-long conflict. And many were rightly...»

«Examining the Influence of Past Travel Experience, General Web Searching Behaviors, and Risk Perceptions on Future Travel Intentions Lori Pennington-Gray, Tourism Crisis Management Institute, Department of Tourism, Recreation and Sport Management, University of Florida penngray@hhp.ufl.edu Ashley Schroeder, Tourism Crisis Management Institute, Department of Tourism, Recreation and Sport Management, University of Florida Kiki Kaplanidou Tourism Crisis Management Institute, Department of Tourism,...»

«CULTURES OF RESILIENCE Ideas Edited by Ezio Manzini 101 and Jeremy Till 25 Contributors: Patricia Austin,82 Marsha Bradfield,44 Carole Collet,78 David Cross,44 Neil Cummings,44 Melanie Dodd,39 Rebecca Earley,73 Anne Eggebert,96 Lorraine Gamman,66 Silvia Grimaldi,58 Bridget Harvey,73 Jane Penty,87 Alison Prendiville,54 Sarah Temple,48 Adam Thorpe,29 Kim Trogal,34 Dilys Williams 92 and Amanda Windle 62 A Project from across the University of the Arts London CULTURES OF RESILIENCE Ideas A Project...»

«Scottish Curling-Ice Group GOOD ICE Overview What is good ice? Everyone has his own opinion, often influenced by whether the game had been won or lost. Some draw, in places, at times was a description used after a competition – that was definitely NOT good ice. Not bad is a common reply after a game – not bad does not equal good. Okay does not mean good either. Yet, when a sheet of average curling ice is compared to a sheet of flipover ice, where the skating marks were still there for all...»

«AUTHOR’S SUMMARY OF PHD DISSERTATION ZRÍNYI MIKLÓS NATIONAL DEFENCE UNIVERSITY Doctorate Council ATTILA BLEIER Modernization of the fixed communication system of the Hungarian Army Author’s summary and official reviews Budapest 2010 ZRÍNYI MIKLÓS NATIONAL DEFENCE UNIVERSITY ATTILA BLEIER Modernization of the fixed communication system of the Hungarian Army Author’s summary and official reviews Scientific Leader: Prof. Dr. Rajnai Zoltán eng. colonel, university professor Budapest 2010...»

«19 May 2014 Address to Shareholders A presentation to the 53rd Annual General Meeting of Leighton Holdings Limited by the Chairman, Mr Robert (Bob) Humphris OAM. Introduction It is a pleasure to announce that the Leighton Group delivered a solid result for shareholders in 2013 reporting an underlying Net Profit After Tax 1 of $584 million. Our CEO, Marcelino Fernández Verdes, will provide a more detailed review of the performance of the Group’s operations for the year in his address. Given...»

«Republican Party of Texas Report of the Permanent Committee on Platform and Resolutions as Amended and Adopted by the 2016 State Convention of the Republican Party of Texas 1 2 PREAMBLE Affirming our belief in God, we still hold these truths to be self-evident, that all men are created equal, that they are 1 endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty and the Pursuit of Happiness. Throughout the world, people dare to dream of freedom and...»

«Reading Summaries for Development General Spring 2005 Jim Berry, Greg Fischer, Raymond Guiteras, and Tom Wilkening1 These reading summaries are NOT intended to substitute for reading the articles. As you’ll see, we leave out a lot of stuff and mess up much of what we include. This is a public good. All that we ask is that (1) you use this at your own risk—we certainly made errors on the general, we may have made some here and (2) if you make any changes or additions, you send them back to...»

«yale program on financial stability, case study 2014-2e-v1 december 1,2014 JPMorgan Chase London Whale E: 1 Supervisory Oversight Arwin G. Zeissler 2 Andrew Metrick 3 Abstract As a diversified financial service provider and the largest United States bank holding company, JPMorgan Chase (JPM) is supervised by multiple regulatory agencies. JPM’s commercial bank subsidiaries hold a national charter and therefore are regulated by the Office of the Comptroller of the Currency (OCC). Since the...»

«Finance, Mining and Sustainability BY:.exploring sound investment decision processes. United Nations Environment Programme Mining Department • World Bank Group Mining Minerals and Sustainable Development Project 2001 2002 T IO NAL B A N NA K ER F T O IN R WORLD BANK REC T EN ON PM ST O RU L VE CT ION AND DE REPORT This report, drafted by UNEP, provides an overview of the UNEP, World Bank, and Mining Minerals & Sustainable Development (MMSD) initiative investigating the role of financial...»

«FAI Best Production Performance Award 2015 for Complex Fertilizers Plant Shri Ananth Kumar, Hon’ble Union Minister of Chemicals & Fertilizers, Govt. of India handing over FAI Best Production Performance Award 2015 for Complex Fertilizers Plant for RCF Trombay Unit to Shri C.M.T. Britto, Director (Technical) in presence of Shri Hansraj Ahir Hon’ble Union Minister of State for Chemicals & Fertilizers, Shri Anuj Kumar Bishnoi, I.A.S, Secretary (Fertilizers), Shri Abir Banerjee, Executive...»

«FINANCE IN VALUE CHAIN ANALYSIS—A SYNTHESIS PAPER microREPORT #132 OCTOBER 2008 This publication was produced for review by the United States Agency for International Development. It was prepared by DAI.FINANCE IN VALUE CHAIN ANALYSIS—A SYNTHESIS PAPER microREPORT #132 The authors’ views expressed in this publication do not necessarily reflect the views of the United States Agency for International Development or the United States Government. CONTENTS INTRODUCTION OBJECTIVE DEFINITION...»

<<  HOME   |    CONTACTS
2016 www.dissertation.xlibx.info - Dissertations, online materials

Materials of this site are available for review, all rights belong to their respective owners.
If you do not agree with the fact that your material is placed on this site, please, email us, we will within 1-2 business days delete him.