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«SUMMARY OF PROFESSIONAL QUALIFICATIONS  Extensive background in staff recruitment and retention  Staff training and development  Superb ...»

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Dr Muhammed Hashem Alzweiri

BSc, MSc, PhD Pharmacy

Associate Professor of Pharmaceutical Analysis

Department of Pharmaceutical Sciences,

Faculty of Pharmacy, The University of Jordan

Amman 11942 - Jordan

Tel. Office 00962-6-5355000 Ext. 23365

Tel. Home 0096265105291 - Fax. 0096265232899

Mobile: 0798513560

E-mail: m.alzweiri@ju.edu.jo

SUMMARY OF PROFESSIONAL QUALIFICATIONS

 Extensive background in staff recruitment and retention  Staff training and development  Superb written and oral communication skills  Organizational and Strategic Planning

GENERAL INFORMATION

Date of Birth : Jan. 09, 1975 Place of Birth : Alshouback - Jordan.

Nationality Jordanian Marital Status : Married, with three Children

EDUCATION

1- Ph.D. in Pharmacy (Pharmaceutical Analysis, LC-MS metabonomics), 2009, Strathclyde University, Glasgow, UK.

Dissertation: “Investigations and optimizations of metabonomics as a clinical tool of analysis” 2- MSc. in Pharmacy (Pharmaceutical Sciences), 2003, The University of Jordan. Thesis: “synthesis and characterization of novel chiral polymer/metal composites and their evaluation as new stationary phase for chromatographic separation of optical isomers.”

4. B.Sc. in Pharmacy ( Pharmacy), 1998, Faculty of Pharmacy, The University of Jordan, Jordan.

LANGUAGES

Arabic Mother Tongue English Very good

ACADEMIC APPOINTMENTS

 22/4/2013-tell now Associate Professor, Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman-Jordan  26/8/2009-22/4/2013 Assistant Professor, Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman-Jordan.

 15/3/2009-26/8/2009 Full-time Lecturer in Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman- Jordan.

 17/3/2003 –12/9/2005 Teaching Assistant, Faculty of Pharmacy, The University of Jordan, Amman-Jordan.

ADMINISTRATIVE ACTIVITIES AND POSITIONS

 Dean assistant for quality affairs, Faculty of Pharmacy, The University of Jordan, Amman-Jordan (2014-tell now).

 Head of department of pharmaceutical science in the University of Jordan 2011-2013  Dean assistant for student affairs, Faculty of Pharmacy, The University of Jordan, Amman-Jordan (2009-2011).

Main Responsibilities:

- Organizing course and lab sessions according to the facilities of the faculty.

- Supervising activities of pharmacy students in and outside the faculty.

- Participation of preparation of curriculum and planning for semester courses.

- Responsible for conveying student opinions and suggestions to the academic staff and to the administrative group.

- Calling for activities and meetings to inspire students with responsibility spirit toward the faculty and its amenities.

- Coaching and helping students to solve their personal problems.

- Fostering and encouraging students to participate in the faculty research.

 Member of Department Council (2009-tell now).

NATIONWIDE ACTIVITIES and CONSULTATION

1 Associate Member, Royal Society of Chemistry (United Kingdom), Membership No.403949, 2008 2 Judge and instructor in “Research in Residence” program for school students (United Kingdom), 2008.

3 SANA Pharmaceutical Company, Faculty for Factory (FFF) program, 2010.

4 Membership of bioequivalence committee -JFDA, 2010-2012 5 Member in the committee of re-evaluating the foundations of the adoption of pharmaceutical factories 2012-2013 6 Membership of clinical studies committee -JFDA, 2013-tell now 7 Referee for international iournal of physical chemistry, pharmaceutical biology, chromatographia acta and Jordanian journal of pharmaceutical sciences. 2008-till now 8 Member of Courses Evaluation Committee, Faculty of Pharmacy, University of Jordan.

PUBLICATIONS

1- Muhammed Alzweiri, David G. Watson, Chris Robertson, Graeme J. Sills, John A. Parkinson. 2008. Comparison of Different Water Miscible Solvents for the Preparation of Plasma and Urine Samples in Metabolic Profiling Studies. Talanta 74 1060–1065.

2- Muhammed Al Zweiri, Graeme J. Sills, John Paul Leach, Martin J. Brodie, Chris Robertson, David G. Watson, John A. Parkinson. 2010. Response to drug treatment in newly diagnosed epilepsy: A pilot study of 1H NMR- and MS-based metabonomic analysis. Epilepsy Research. 88 (2-3). 189-195 3- Yusuf Mohammad Al-Hiari, Amjad M. Qandil, Rufaida M. Al-Zoubi, Muhammed H. Alzweiri, Rula M.Darwish, Ghassan F. Shattat and Tariq M. Al-Qirim. 7-(3-Chlorophenylamino)-1-cyclopropyl-6-fluoro-8-nitro-4-oxodihydroquinoline-3-carboxylic Acid. Molbank 2010, M669 4- Muhammed Alzweiri, John Parkinson, David W. Watson and Steve Steer.

2011. Microscopic trends in methanol/water and acetonitrile/water systems.

Jordan Journal of Pharmaceutical Sciences. 4(1):20-28 5- Yusuf M. Al-Hiari, Ashok K. Shakya, Muhammed H. Alzweiri, Tariq M.

Al-Qirim, Ghassan F. Shattat and Mustafa M. El-Abadleh. 2011. Synthesis and Antibacterial Properties of New N4- acetylated Hexahydro-2,7dioxopyrido[2,3-f]quinoxaline-8-carboxylic acids. Journal of Enzyme Inhibition and Medicinal Chemistry. 26(5):649-656 6- Muhammed Alzweiri, Ali Al Sarhan, Kamal Mansi, Mohammad Hudaib and Talal Aburjai. 2011. Ethnopharmacological Survey of Medicinal Herbs in Jordan, The Northen Badia Region. Journal of ethnopharmacology. 137:27– 35 7- Yusuf M. Al-Hiari, Amjad M. Qandil, Rufaida M. Al-Zoubi, Muhammed H.





Alzweiri, Rula M. Darwish, Ghassan F. Shattat, and Tariq M. Al-Qirim. 2012.

Synthesis and Antibacterial Activity of Novel 7-haloanilino-8nitrofluoroquinolone Derivatives. Medicinal Chemistry Research. 21:1734– 1740 8- Muhammed Alzweiri, Yusuf M. Al-Hiari, Talal Aburjai and Osama AbdelAldaem. 2012. On-column approach in HPLC-UV analysis of nonchromophoric compounds using azelaic acid as a model. Jordan Journal of Pharmaceutical Sciences. 5(3): 243-251 9- Safwan Shiyab, Mohamed Shatnawi, Rida Shibli, Muhammed Alzweiri, Muhannad Akash, and Talal Aburjai. 2012 Influence of developmental stage on yield and composition of Origanum syriacum L. oil by multivariate analysis. Journal of Medicinal Plants Research. 6(15):2985-2994 10- Muhammed Alzweiri and Yusuf Al-Hiari. 2013. Evaluation of vanillic acid as inhibitor of carbonic anhydrase isozyme III by using a modified HummelDreyer method: Approach for drug discovery. Biomedical chromatography.

27(9):1157-61.

11- Talal Aburjai, Muhammed Alzweiri, and Yusuf M. Al-Hiari. 2011.

Temperature and pressure behaviours of methanol, acetonitrile/water mixtures on chromatographic systems. American Journal of Analytical Chemistry. 2(8): 934-937.

12- Muhammed Alzweiri, David Watson, and John Parkinson. 2012.

Metabonomics as a Clinical Tool of Analysis, LC-MS approach. Journal of Liquid Chromatography & Related Technologies. 36(1): 94-115 13- Muhammed Alzweiri, Ruba Tarawneh and Mohammad A. Khanfar. 2013.

Gas chromatography/trace analysis of derivatized azelaic acid as a stability marker. Journal of Separation Science. 36(19):3200-5.

14- Hayder Al-domi, Muhammed Alzweiri, Imad Hamdan and Ziad Jardat. 2013.

In vitro evaluation of potential complexation between bovine insulin and bovine serum albumin. Biomedical chromatography. Accepted.

15- Ali Alsarhan, Kamal Mansi, Talal Aburjai, Ahed Al-Khatib, Muhammed Alzweiri and Naznin Sultana. 2013. HSP70 and iNOS biomarkers in evaluating the healing properties of Rubia tinctorum. European Scientific Journal. vol.9, No.15 16- Muhammed ALzweiri and Yusuf Al-hiari. 2013. Evaluation and standardisation of hydroxytyrosol antioxidant activity in olive leaf extract.

Jordan Journal of Pharmaceutical Sciences. Volume 6, No. 3, 2013.

17- Sanaa K. Bamradweel, Aman Ishaqat and Muhammed Alzweiri. 2014. Dserine in Neurobiology: CNS Neurotransmission and Neuromodulation. The Canadian Journal of Neurological Sciences. 41 (2) 164-176 18- Yusuf M Al-Hiari, Violet N Kasabri, Ashok K Shakya, Muhammad H Alzweiri, Fatma U Afifi, Yasser K Bustanji, Ihab M Al-Masri. 2014.

Fluoroquinolones: Novel class of gastrointestinal dietary lipid digestion and absorption inhibitors. Medicinal Chemistry Research.1-11 19- Manal AL-Najdawi, Yusuf Al-Hiari, Tariq Al-Qirim, Ghassan Shattat, Muhammad Alzweiri, and Ghassan Abu Sheikha. 2014. Synthesis and Pharmacological Evaluation of Novel Unsubstituted Indole-Anthraquinone Carboxamide Derivatives as Potent Antihyperlipidemic Agents. Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences.

20- Alzweiri M, Shudeifat M, Al-Khaldi K, Al-Hiari Y, Afifi F. U. 2014.

Acetylated ferulenol-oxy-ferulenol as a proposed marker for fresh ferula toxicity: A metabolomic approach. Journal of Liquid Chromatography & Related Technologies.

21- Muhammed Alzweiri, Qosay Al-Balas and Yusuf Al-Hiari. 2014.

Chromatographic evaluation and QSAR optimization for benzoic acid.

Journal of enzyme inhibition and medicinal chemistry.

22- Yusuf M Al-Hiari, Ashok K Shakya, Muhammed H Alzweiri, Talal Aburjai, Rana Abu-Dahab. 2014. Synthesis And Biological Evaluation Of Substituted Tetrahydro-1h-Quino [7, 8-B][1, 4] Benzodiazepine-3-Carboxylic Derivatives.

23- SK Bardaweel, RM Darwish, MH Alzweiri, YM Al-Hiari. 2014. Synergism and Efficacy of Some Naturally Occurring D-amino Acids Against Clinically Relevant Bacterial and Fungal Species. Jordan Journal of Pharmaceutical Sciences 7 (3).

24- Muhammed Alzweiri, Ibrahim M. Alrawashdeh and Sanaa K. Bardaweel.

2014. The development and application of novel IR&NMR-based model for the evaluation of carminative effect of Artemisia judaica L. essential oil.

International journal of analytical chemistry.

25- Muhammed Alzweiri, Mohammed Khanfar, and Yusuf Al-hiari. 2014.

Variation in GC-MS responses between analytes and deuterated analogs.

Chromatographia.

BOOKS 1- Muhammed Alzweiri. Neutral and acidic nitrogen compounds.

Pharmaceutical and Medicinal Chemistry book. David G Watson.

Elsevier 2011.

TEACHING COURSES

1- Medicinal chemistry III (Undergraduate level) 2- Instrumental analysis (Undergraduate level) 2- Analytical chemistry (Undergraduate level) 3- Applied chromatography. (Undergraduate level) 4- Organic chemistry (MSc level) 5- Drug identification (MSc level) 6- Advanced spectroscopy (PhD level) 7- Advanced chromatography (PhD level) 8- Spectroscopic analysis (PhD level)

CONFERENCES, MEETINGS AND WORKSHOPS

3d 1- Jordanian international pharmaceutical conference. Alzaytoona private university of Jordan. Metabonomics as clinical tool of analysis, 2010.

13th 2- conference of Jordan pharmaceutical association. Presentation: Macro and Microscopic Trends in Methanol/Water and Acetonitrile/Water Systems, 2010.

3- European biomarker summit. Lisbon, Portugal. Poster: Can Metabolic Markers in Blood Serum be Found for Distinguishing Anti-Epileptic Drug Responders from Non-Responders Using a Metabonomic Approach? 2008.

11th 4- international conference on chemistry and its role in development ICCRDEgypt. Influence of developmental stage on yield and composition of Origanum syriacum L. oil by multivariate analysis 2013.

5- Eurasia Conference on Chemical Sciences-11. 2010. The Use of Mass Spectroscopy (MS) in Detection and Elucidation of Low-Abundant Metabolites (LAM). Dead Sea.

14th scientific congress of association of pharmacy in the Arab world. Ajman 6University 2011. Development of a safe formula for treating acne vulgaris 15th congress of pharmacy from Romania (CNFR 2014). Oral presentation:

7Evaluation of vanillic acid as inhibitor of carbonic anhydarse isozyme III by using Hummel-Dreyer method: Approach for drug discovery”.

RESEARCH GRANTS

1- Pharmacodynamic evaluation and marker standardization of Paronychia argentea (Rijl El Hmameh) as a diuretic herb. JD15,000- Scientific researchThe University of Jordan 2- Convenient synthesis and bioproperties of heterocycles [H]-fused onto 4oxoquinoline-3-carboxylic acid: substituted hexahydro [1,4] diazepino [2,3-H] quinoline-9-carboxylic acid. JD20,000- Scientific research- The University of Jordan.

3- Evaluation and characterization of a novel possible diabetogenic bovine milk protein. JD30,000- Scientific research- The University of Jordan.

4- Discovery of inhibitors for carbonic anhydrase iii and structural activity relationship through chromatographic vacancy peak.. JD10,000. Scientific research- The University of Jordan 5- Purification of Pathogenesis Determinant proteins for the identification of novel antimicrobial targets: Polyphosphate Kinase 1 active site characterization. JD95,000. Scientific Research Support Fund.

6- Relying on 3D shape of benzoic acid derivatives as anti-obesity by using protein X-ray crystallography. JD130,000. Scientific Research Support Fund

THESIS SUPERVISON AND EXAMINATION

MSc Students Supervision 1- MSC thesis: Mariam Alsyed. "Physical and chemical stability of etoricoxib in oral liquid suspensions. An investigational study using microcrystals and nanocrystals of etoricoxib".

2- MSC thesis: Yahya Tabaza. " Implementation of chemometrics in studying drug-excipient compatibility for ciprofloxacin as a model. Quality by design approach".

3- MSC thesis: Hamsa Alakad. "Investigating physicians’ perception of pharmaceutical trade names in Jordan’s private market: simulated and realworld setting approaches".

4- MSC thesis: Nada Jarar. “Screening of nicotinic acid analouges as potential carbonic anhydrase III inhibitors”.

5- MSC thesis: Belal Al-Remaoy. “Preparation of an acyl ester of Risedronate and its evaluation as a prodrug for transdermal drug-delivery”.

6- MSC thesis: Sara Al-Maraebyeh. “A prodrug approach to enhance azelaic acid percutaneous absorption.” 7- MSC thesis: Haneen Khalid. “Screening and size effect investigation of nicotinic acid analogues as potential Carbonic anhydrase III inhibitor to treat hyperlipidemia”.



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