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«A M E R I C A N B R A I N T U M O R A S S O C I AT I O N Ependymoma A C K N OWLEDGEM ENTS ABOUT THE AMERICAN BRAIN TUMOR ASSOCIATION Founded in 1973, ...»

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A M E R I C A N B R A I N T U M O R A S S O C I AT I O N

Ependymoma

A C K N OWLEDGEM ENTS

ABOUT THE AMERICAN

BRAIN TUMOR ASSOCIATION

Founded in 1973, the American Brain Tumor

Association (ABTA) was the first national nonprofit

organization dedicated solely to brain tumor research.

For over 40 years, the Chicago-based ABTA has been providing comprehensive resources that support the complex needs of brain tumor patients and caregivers, as well as the critical funding of research in the pursuit of breakthroughs in brain tumor diagnosis, treatment and care.

To learn more about the ABTA, visit www.abta.org.

We gratefully acknowledge Regina Jakacki, MD, director, Pediatric Neuro-Oncology Program, Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania and Beverly LaVally, RN, of the Dana-Farber Cancer Institute, Boston, for their review of this edition of this publication.

This publication is not intended as a substitute for professional medical advice and does not provide advice on treatments or conditions for individual patients. All health and treatment decisions must be made in consultation with your physician(s), utilizing your specific medical information. Inclusion in this publication is not a recommendation of any product, treatment, physician or hospital.

COPYRIGHT © 2015 ABTA

REPRODUCTION WITHOUT PRIOR WRITTEN PERMISSION

IS PROHIBITED

A MERICAN BRAIN T UM O R AS S O CI ATI O N

Ependymoma

INTRODUCTION

Any tumor that arises from the glial cells in the brain is called a “glioma.” Glial cells provide support and protection for the nerve cells, or neurons, in the brain.

One type of glioma is the ependymoma. Ependymomas arise from ependymal cells that line the ventricles of the brain and the center of the spinal cord. Occasionally, ependymal cells are found within the brain itself.

Ependymomas are soft, grayish or red tumors which may contain cysts or mineral calcifications.

The words “supratentorial” and “infratentorial” describe the location of the ependymoma within the brain.

The tentorium is a thick membrane that separates

CE R E B RA L H E M I SPH ERES

L ATERA L V EN TRICL E

TH IRD V EN TRICL E Above the tentorium is “supratentorial” TEN TO RIU M Below the tentorium is F O U RTH “infratentorial” V EN TRICL E or the “posterior fossa” S PIN A L CO RD Tentorium www.abta.org the top two-thirds of the brain from the bottom third.

Supratentorial ependymomas occur above the tentorium.

This area includes the cerebral hemispheres, as well as the lateral and the third ventricles. Infratentorial ependymomas occur below the tentorium. This area, also called the posterior fossa, includes the fourth ventricle, the brainstem and the cerebellum.

There are four major types of ependymomas:

myxopapillary ependymomas, subependymomas, ependymomas and anaplastic ependymomas.

–  –  –

Most grade I tumors do not recur after complete surgical removal. Grades II and III tumors need additional treatment and have a higher likelihood of recurring.

Myxopapillary ependymomas tend to occur in the lower part of the spinal column. Subependymomas usually occur near a ventricle. Both are slow growing, and are considered to be low-grade or grade I tumors.

Ependymomas are the most common of the ependymal tumors, and are considered grade II tumors. These tumors are usually located along, within or adjacent to the ventricular system, often in the posterior fossa or in the spinal cord.

Anaplastic ependymomas are high-grade tumors (grade III) and tend to be faster growing than low-grade tumors.

They most commonly occur in the posterior fossa.

–  –  –

INCIDENCE Ependymomas are relatively rare tumors, accounting for 2–3% of all primary brain tumors. However, they are the third most common brain tumor and spinal cord tumor in children. About 30% of pediatric ependymomas are diagnosed in children younger than three years of age.

The location of ependymomas in adults tends to be different than the location of ependymomas in children.

In adults, 60% of these tumors are found in the spinal cord. In children, 90% of ependymomas are found in the brain, with the majority located in the posterior fossa.

CAUSE The cause of ependymomas, like that of other brain tumors, is unknown. Much more research is necessary to determine whether this is indeed a factor in humans, since these particular viruses do not normally affect humans.

SYMPTOMS Symptoms of an ependymoma are related to the location and size of the tumor. In neonates and infants, enlargement of the head may be one of the first symptoms. Irritability, sleepiness and vomiting may develop as the tumor grows. In older children and adults, nausea, vomiting and headache are the most common symptoms. These are usually signs of increased pressure or hydrocephalus, which develops if the tumor blocks the drainage of cerebrospinal fluid (the liquid that bathes the brain).





Fatigue is a common symptom people experience during the course of the illness.

Headaches are a common symptom, and are generally worse in the morning. A tumor near the brainstem may cause one or both eyes to cross, balance problems or trouble walking.

www.abta.org Neck pain may result from a tumor growing near the brainstem or the upper part of the spinal cord.

Seizures, headaches and weakness of one side or one part of the body may occur with a tumor in the cerebral hemispheres. Spinal cord tumors often cause leg or back pain which can be severe enough to awaken the person from sleep. Tingling sensations, numbness, or weakness in the arms or legs may also occur. Difficulty

–  –  –

with bladder or bowel control may be caused by an ependymoma in the lower part of the spine.

DIAGNOSIS Magnetic Resonance Imaging (MRI) scans and/or Computerized Axial Tomography (CT) scans are required for patients suspected of having a brain tumor.

The MRI, which uses radio waves and a magnetic field, provides details about the location of the tumor and which parts of the brain or spinal cord are involved prior to surgery. CT scanners are sophisticated x-ray devices connected to computers. CT scans are useful

6 AMERICAN BRAIN TUMOR ASSOCIATION

E P E NDYM OM A for getting a quick view of the brain to see if there is a tumor and whether it has caused hydrocephalus (the buildup of cerebrospinal fluid in the brain). However, only microscopic examination of a sample of tissue obtained during surgery or biopsy confirms the exact diagnosis.

About 10–15% of ependymomas spread, or metastasize, through the cerebrospinal fluid. The tumor cells then may grow independently, in or along the spinal cord, or rarely, in other places in the brain. Infratentorial tumors are more likely to spread to the spine than supratentorial tumors.

Ependymomas almost never spread outside of the central nervous system (brain and spinal cord). A spinal MRI scan and lumbar puncture (spinal tap) will be performed to determine whether the tumor has spread to the spine and/ or spinal fluid. The fluid obtained during the spinal tap will be tested for the presence of tumor cells. Your doctor will decide the appropriate time to perform these tests. The results are used to guide treatment.

TREATMENT With improved neurosurgical and radiation therapy techniques, patients with ependymomas have a significantly increased chance of survival, particularly if they are cared for by an experienced multidisciplinary team of medical professionals at an established pediatric or adult cancer center with a brain tumor specialty.

–  –  –

Cerebral fluid flow The treatment of an ependymoma varies depending on its location, grade, and whether the tumor has spread to the spine.

SURGERY The most important first step in the treatment of an ependymoma is surgery to remove as much tumor as possible. Studies clearly show that patients whose tumor can be “grossly” removed (removing all tumor that can be seen) have the best chance of long-term survival.

The amount of tumor that can be removed, however, depends on the location of the tumor. High-powered microscopes in the operating room help the surgeon see tumor located in and around the ventricles or the brainstem. Removal of all visible tumor is not always possible, especially if the tumor is attached to the brainstem or involves other important areas of the brain.

In children, ependymomas often fill the fourth ventricle and extend through its floor into the brainstem, or out to the side of the lower brainstem where the nerves that affect swallowing are located, making safe removal of those portions of tumor difficult.

8 AMERICAN BRAIN TUMOR ASSOCIATION

E P E NDYM OM A Hydrocephalus is often present at the time of diagnosis when the tumor has blocked the outflow of cerebrospinal fluid. Tumor removal may open up these fluid pathways, although some patients will still require the placement of a ventriculoperitoneal (VP) shunt to bypass the blockage. Many surgeons will place a temporary external ventricular drain during surgery. This is used to drain off excess fluid for a few days after the surgery. If it cannot be removed after a few days, a permanent shunt may be required.

An MRI of the brain should be done within a day or two of surgery to determine how much visible tumor remains, if any.

RADIATION Radiation therapy is usually recommended for older children (age dependent on the location of the tumor) and adults following surgery, even if all visible tumor was removed.

The age of the patient, the location of the tumor and whether it has spread are considered in treatment planning. If the tumor is localized, radiation therapy is usually given just to that area of the brain. If the tumor has spread, radiation is usually given to the entire brain and spine, with an extra amount of radiation (called a boost) given to the area of the brain where the tumor started.

There are different methods of administering radiation.

External beam radiation is given five days a week for six weeks. Conformal beam radiation therapy is a type of external beam radiation that contours the radiation beams to the shape of the tumor. Stereotactic radiosurgery is a way of giving a single or a few high doses of precisely focused radiation to the tumor. This is often used for ependymomas that grow back after

–  –  –

Because of the long-term side effects of radiating young children, chemotherapy may be used to delay radiation therapy in the very young child. If the tumor grows despite the chemotherapy, radiation therapy may be considered.

CHEMOTHERAPY

Chemotherapy uses special drugs to kill tumor cells.

Scientists continue to study the role of chemotherapy and when it is best used. It is not clear whether using chemotherapy in the treatment of patients with newly diagnosed ependymomas makes a difference. Some tumors respond to treatment for awhile, while others continue to grow. Chemotherapy may also be used to delay radiation for infants and young children, or to treat tumors that have grown back after radiation therapy. It is not clear which chemotherapy drugs are the most effective against ependymomas. Drugs such as cisplatin and carboplatin may cause shrinkage in about half of ependymomas, although not usually for a long time. Either standard chemotherapy, or experimental chemotherapy as part of a clinical trial, are often used for patients whose tumors regrow after radiation.

TREATMENT SIDE EFFECTS

Some treatment, while increasing survival, may have significant side effects on children. Prior to treatment your child may undergo neuropsychological testing.

Those results can be used as a baseline for future evaluations.

Surgery, particularly for infratentorial ependymomas, may result in the development or temporary worsening of balance, speech or swallowing. Most of these changes will improve over several weeks or months. The negative effects of radiation therapy

–  –  –

on the brain are of great concern to those who treat children with brain tumors. A significant number of children, particularly those who are very young at the time of treatment, experience some degree of decreased intellect and learning problems following radiation to large areas of the brain. The severity of the learning problems is correlated with the location and amount of brain radiated and inversely related to the age of the child. Radiation to just the back part of the brain does not cause as many problems as does radiation to the upper part of the brain. When the upper part of the brain is radiated, teachers and parents often report significant problems with reading, math and short-term memory. The role of special education programs to help these children develop their strengths and identify their weaknesses is of prime importance.

Older children and adults tend to have fewer problems.

Poor growth may be a consequence of radiation therapy damage to the hypothalamus or pituitary gland which produce several important hormones. Replacement of these hormones is often necessary, under the supervision of a pediatric endocrinologist. Radiation to the spine at a young age may also cause short stature. Weakening of the muscles next to the spine is also possible.

The long-term effects of chemotherapy in children are still being studied. Platinum-based drugs often cause hearing loss, as can radiation therapy when

–  –  –

www.abta.org delivered near the ears. Both radiation and chemotherapy can increase the chance of developing a second cancer or brain tumor. Some chemotherapy can cause infertility.



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