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«The Eye and The Chip World Congress on Artificial Vision 7TH BIENNIAL WORLD CONGRESS on Artificial Vision SEPTEMBER 9 - 11, 2012 Detroit Marriott ...»

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The Eye and The Chip

World Congress on Artificial Vision



on Artificial Vision

SEPTEMBER 9 - 11, 2012

Detroit Marriott Renaissance Center


A division of the Henry Ford Department of Ophthalmology

The Eye and The Chip

The Eye and The Chip

The Eye and The Chip


WELCOME................................................................................. 1


AND HENRY FORD DEPARTMENT OF OPHTHALMOLOGY...................................... 3 ACCREDITATION............................................................................ 4 CONGRESS SCHEDULE....................................................................... 5 FACULTY LIST.............................................................................. 10 FACULTY BIOGRAPHIES AND ABSTRACTS.................................................... 13 POSTERS.................................................................................. 51 BARTIMAEUS RECIPIENTS.................................................................. 53 RECOGNITION............................................................................. 54 Live Streaming and Audio-Visual Services Provided by Dynasty Media Network.

The Eye and The Chip Welcome On behalf of the Henry Ford Department of Ophthalmology, I am pleased to welcome you, along with Dr. Philip Hessburg, to this year’s The Eye and The Chip.

In June of this year, Henry Ford Health System signed a merger agreement with The Detroit Institute of Ophthalmology

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In years gone by, the Board of Directors of the DIO were very sensitive to our acting as “neutral broker” in this field of research. We were trusted by each of you since we did not have a “dog in the fight.” That remains true. Henry Ford Health System is not involved in developing a device of its own.

It is, though, tremendously interested in lifting a portion of the burden of those suffering the loss of vision. And that has been the driving force of the DIO for forty years.

We wish to thank all of our sponsors for their financial commitment. The Institute views sponsorship as an endorsement of our goal to move forward the day when blind people recover some level of useful vision and function independently. The Eye and The Chip unequivocally furthers this goal.

The premise on which collegial research congresses are built is that collegiality facilitates collaboration and that collaboration accelerates progress. When groups from Australia come to know investigators in Korea or Germany, there is reason to believe that this acceleration will occur. The proof of that premise is nicely presented in this statement from

an individual in Australia:

The Eye and The Chip has been instrumental in us moving forward and securing funding. It also allowed us to form some marvelous collaborations and exchanges. We have a joint project with Dr Jong-Mo Seo from Korea on surgical approaches and electrode manufacture. Also Dr. Robert Wilke from Professor Zrenner’s group in Tubingen (Germany) has come to Australia for the next few years to work on mathematical models and in-vitro experiments to better understand electrical stimulation of the retina.”

- Nigel Lovell, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia Our congratulations and appreciation to you for your presentations, your research, and your unshakeable faith in the possibility of artificial human vision.

Sincerely yours, Philip C. Hessburg, M.D.

Medical Director Detroit Institute of Ophthalmology Henry Ford Department of Ophthalmology pchessburg@dioeyes.org eyeson.org

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As of June 2012, The Detroit Institute of Ophthalmology is a division of the Henry Ford Department of Ophthalmology, and is recognized as its research education arm. The DIO programs are continuing under the Department of Ophthalmology.

Current programs include:

Research Congresses The Eye & The Chip: A research congress dedicated to accelerating progress toward the goal of developing artificial vision by providing a format for exchange of scientific advances and discussion among internationally recognized experts.

The Eye & The Auto: A research congress focused on the relationship between vision and the safe operation of a motorized vehicle.

Support for the Visually Impaired With help from its volunteer arm, the Friends of Vision, services for the visually impaired include support groups, the Martha F. Gorey Resource Center (offering low vision aids), and the AT&T Computer Training Lab for the Visually Impaired.

Public & Professional Education Program materials and information on vision loss are distributed to physician offices, local libraries and through community events. The DIO also holds seminars for emergency physicians and hosts ophthalmology resident lectures.

DIO Program Funding The DIO programs are funded by contributions from individuals, foundations, corporations, and from proceeds from its fundraising events – EyesOn Design car show and associated events, EyesOn Design Awards for Design Excellence at the North American International Auto Show, and participation in the Detroit Free Press Marathon through Steps for Sight.


One of the largest ophthalmology practices in the U.S., the Henry Ford Department of Ophthalmology provides convenient, high-quality and compassionate care, treating more than 55,000 patients annually at 12 locations throughout southeast Michigan. Board-certified physicians provide comprehensive and coordinated adult and pediatric eye care, as well as specialized medical and surgical treatment for all eye conditions. Advanced treatment options are offered, led by continuous research and evidence-based medicine.

The department includes the nationally recognized Henry Ford Center for Vision Rehabilitation and Research, providing rehabilitation to help people with low vision conditions.

The Eye and The Chip


Henry Ford Health System is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.


Henry Ford Health System designates this live course for a maximum of 23.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


In compliance with the ACCME Standards for Commercial Support, all individuals in a position to control/influence the content of this activity are required to disclose relevant financial interests of their own or spouse or partners with any commercial interests and/or non-FDA approved use of a drug or a device that is included in the presentation.

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12:30-1:00 p.m. Encoder Technologies for Intelligent Artificial Visual Systems Professor Rolf Eckmiller (em) Ph.D. (Germany)

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1:15-1:45 p.m. Retinal Ganglion Cells Can Encode Visual Stimuli through Spike Train Coherence Steven F. Stasheff, M.D., Ph.D. (Iowa)

–  –  –

TUESDAY, SEPTEMBER 11, 2012 7:30-8:00 a.m. CONTINENTAL BREAKFAST – Mackinac Ballroom Hallway 8:00 a.m. CONFERENCE PROCEEDINGS – Mackinac Ballroom

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8:00-8:30 a.m. A Cortical Visual Neuroprosthesis for Individuals With Profound Blindness:

Technological Developments and Preliminary Human Studies Eduardo Fernandez, M.D., Ph.D. (Spain)

–  –  –

Advances in CNS and Retina Implant Technology Abstract: We have designed and fabricated flexible microelectrode arrays that provide stimulation to discrete populations of neurons and provide real-time feedback. These arrays are tailored to fit the geometry of the implant site and functionality desired. We have encapsulated the arrays in semiconductor biocompatible materials and selectively coat the system using biologically inert organic materials. For the development and long-term effectiveness of implantable prosthesis, an in vitro investigation of neural cell interactions with the implant surface is extremely important. To enhance the performance of the prosthesis have optimized neural electrode interactions by increasing biocompatibility and minimizing the growth of scar tissue mediated by glial cells for all surfaces we use for constructing the microelectrode arrays. This central nervous system electrode array is integrated with wireless power and communication linked by high frequency magnetic field transmission. This system has been integrated with a 144 independent computer chips that enable parallel or pipelined programming. With instruction times as low as 1400 picoseconds and consuming as little as 7 picojoules of energy, each of the 144 computers can do its work with ultra high speed for a microcontroller and yet at extremely low energy cost, transitioning between running and suspended states in gate delay times. When suspended, each of the computers uses less than 100 nanowatts. We have determined biocompatibility of the microelectrode array through in vitro and in vivo investigations using cultured rat cortical cells grown on the device and direct cortical implants in the rat brain. Through these in vitro and in vivo studies we have established the impedance response of the neurons to the device.

Biography: Dr. Gregory W. Auner is a Strauss/TEAMS (Technology and Engineering Applications in Medicine and Surgery) Endowed Chair and Professor of Electrical and Computer Engineering, Biomedical Engineering, Material Science, and faculty in the Department of Surgery at Wayne State University in Detroit, MI. He is the founder and director of the Smart Sensors and Integrated Microsystems (SSIM) program at WSU. He has developed an array of instruments, sensors and microsystems for federal institutions, research institutions, and industry. Approximately 80% of his research involves the research and development of Energy Devices, DoD and Homeland Security Sensors, biomedical microsystems and BioMEMS systems. Dr. Auner has formed a consortium within the Smart Sensors Program involving the Karmanos Cancer Institute (Ultrasonic Breast Cancer Detection System) and Children’s Hospital of Michigan (Robotic Surgery and RealTime Surgical Diagnostics). His SSIM program, along with the Chiefs of Surgery at the Wayne State University School of Medicine, Detroit Medical Center, Karmanos Cancer Institute, Children’s Hospital of Michigan, Beaumont, Oakwood and Henry Ford Hospital Systems have created the technology and engineering applications in medicine and surgery (TEAMS) which is integrating state of the art science and technology into the field of medicine. He has over 25 patents (issued and pending) in the last several years for chemical, biomedical, and environmental sensors and microsystems. He has over 226 peer reviewed. He is the Co-Founder and Chief Technical Officer at Visca, LLC - a Wayne State University spin-off company which is headquartered in Troy, MI.

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Abstract: An overview of the “high-acuity” retinal implant research program of Bionic Vision Australia will be presented.

The electrode array is made from ultra-nanocrystalline diamond (UNCD) with nitrogen-doped conductive channels.

Electrochemical characterization of UNCD electrodes grown in the presence of nitrogen (N-UNCD) have been shown to exhibit charge injection capacity values as high as 250 µC cm−2 indicating that N-UNCD is a viable material for microelectrode fabrication. The maximum charge injection of N-UNCD can be increased by tailoring growth conditions and by subsequent electrochemical activation. Results obtained from preclinical studies will be presented. In the fully implanted system, the conducting channels are bump-bonded to a stimulating chip that is enclosed in a UNCD capsule, which is hermetically sealed using a laser welding technique. The chip is fabricated using a 65nm process and comprises an array 256 stimulators that can be driven in parallel to give arbitrary patterns of stimulating and return electrodes. This arrangement allows a variety of stimulation strategies to be implemented. The device is implanted epi-retinally and fixed using a retinal tack.

Biography: Prof. Burkitt is the Director of Bionic Vision Australia and Professor in the Department of Electrical and Electronic Engineering at the University of Melbourne.

Prof. Burkitt’s research is in the area of neuro-engineering and he has worked in cochlear implant speech processing and computational auditory neuroscience for over a decade. This work has involved the investigation of various mechanisms of information processing specialised to the auditory system and associated with speech perception. He has published papers on physiological neural processing mechanisms associated with speech that involve specialized networks within the auditory brainstem. This research has been instrumental in his development of new cochlear implant speech processing strategies that have been patented and currently undergoing pilot clinical trials. His recent research interests have involved extending these concepts from the auditory system to the visual system in order to develop visual stimulation paradigms for retinal implants.

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