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«CURRICULUM VITAE 16 September 2015 Name: Walter Churchill Willett Office Address: Department of Nutrition, Room 363, Building 2, 651 Huntington, ...»

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CURRICULUM VITAE

16 September 2015

Name: Walter Churchill Willett

Office Address: Department of Nutrition, Room 363, Building 2, 651 Huntington, Boston,

MA 02115

E-mail: Walter.Willett@channing.harvard.edu

FAX: (617) 432-0464

Education:

1966 Michigan State University

1970 M.D. University of Michigan Medical School 1973 M.P.H. Harvard School of Public Health 1980 Dr. P.H. Harvard School of Public Health, Epidemiology

Postdoctoral Training:

1970-71 Intern in Medicine, Harvard Medical Service, Boston City Hospital 1971-73 Fellow, Family and Ambulatory Medicine, Boston City Hospital 1973-74 Resident in Medicine, Boston City Hospital 1977-80 Research Fellow in Medicine, Harvard Medical School 1979-80 Research Fellow in Medicine, Peter Bent Brigham Hospital

Licensure and Certification:

1970 Michigan License Registration 1971 Massachusetts License Registration 1974 American Board of Internal Medicine Certification

Academic Appointments:

1974-75 Lecturer in Medicine, Faculty of Medicine, University of Dar es Salaam, Tanzania 1975-77 Lecturer in Community Medicine and Head of Community Health Department, Faculty of Medicine, University of Dar es Salaam, Tanzania 1980-84 Assistant Professor of Epidemiology, Department of Epidemiology, Harvard School of Public Health 1984-87 Associate Professor of Epidemiology, Department of Epidemiology, Harvard School of Public Health 1986-92 Lecturer in Medicine, Harvard Medical School l987- Professor of Epidemiology and Nutrition, Harvard School of Public Health 1991- Chairman, Department of Nutrition, Harvard School of Public Health 1992- Professor of Medicine, Harvard Medical School 2010-16 Foreign Adjunct Professor in Nutritional Epidemiology, Karolinska Institutet, Institute of Environmental Medicine (IMM)

Hospital Appointments:

1977-84 Associate in Medicine, Boston City Hospital 1980-82 Jr. Associate in Medicine, Brigham and Women's Hospital l982- Associate Physician, Brigham and Women's Hospital

Other Professional Positions:

1992 D.W. Harrington Visiting Professor, State University of New York at Buffalo

Awards and Honors:

1965 Phi Kappa Phi 1968 Alpha Omega Alpha 1970 Summa Cum Laude, University of Michigan Medical School 1981 Soci

–  –  –

l984-86 NIH Epidemiology and Disease Control Study Section l985-86 Cancer Control Objectives for the Nation: l985-2000, Prevention Working Group l986-87 Visiting Committee, Human Nutrition Research Center on Aging at Tufts University 1992-93 Institute of Medicine, Review of Priorities in Nutrition Research 1992-93 President's Cancer Panel, Subcommittee on Breast Cancer 1993- NIH, Institute of Alternative Medicine Committee on Nutrition 2009- Center for the Study of the President and Congress, Washington, DC

Professional Societies:

–  –  –

Editorial Boards:

1986 Associate Editor, American Journal of Epidemiology 1987-2000 Statistical and Epidemiological Consultant, New England Journal of Medicine 1986 Associate Editor, Cancer Epidemiology, Biomarkers and Prevention 1992- Associate Editor, Cancer Research 1993- Associate Editor, International Journal of Oncology 1993- Associate Editor, Current Reviews in Public Health 1993- Associate Editor, Breast Diseases: An International Journal 2008-2010 Associate Editor, The American Journal of Clinical Nutrition

Honorary Degrees, Honors and Awards

1998 Honorary Degree of Doctor of Science, Michigan State University 2003 Honorary Doctorate, Wageningen University, Netherlands 2007 Honorary Professor, Shanghai Jiao Tong University 2007 Honorary Professor, Huazhong University of Science and Technology 2008 Honorary Degree of Doctor of Laws, University of Dundee, Scotland A. Narrative Report of Research, Teaching, and Clinical Contributions The large majority of my effort for the last two decades has been devoted to research activities.

A central focus has been the development of the field of nutritional epidemiology, which required the creation and validation of questionnaire and biochemical methods to assess dietary intake in large populations. These methods have been incorporated into three large prospective studies comprising approximately 250,000 men and women: Nurses' Health Study I, Nurses' Health Study II, and Health Professional's Follow-up Study. In each of these studies dietary intakes are assessed every two to four years, and follow-up is now up to 33 years. These cohorts, which are now the only large populations with repeatedly measured diets over a long period of time, are now providing a wealth of data on diet and other lifestyle factors in relation to risks of major cancers, cardiovascular diseases, and other chronic illness. Examples of major reports include the relationships between type and amount of dietary fat and risks of breast, colon, and prostate cancers and coronary heart disease; carbohydrate quality and major protein sources in relation to these same diseases, and evaluation of dietary guidelines based on prediction of major chronic disease..

In recent years, my primary classroom teaching responsibility has been Nutritional Epidemiology (NUTEPI 216) at Harvard School of Public Health. In addition, I provide several lectures in the introductory nutrition course (NUT 201) and other courses at the School of Public Health, Harvard Medical School, and the Faculty of Arts and Sciences.





B. Funding Information

–  –  –

C. Report of Current Research Activities My current research activities are primarily based in three large, prospective observational cohorts: Nurses' Health Study I, Nurses' Health Study II, and Health Professional's Follow-up Study. I am a co-investigator in the Nurses' Health Study I and Principal Investigator of the latter two studies. The primary objective of this work is to elucidate the modifiable determinants of these important conditions; dietary factors, physical activity, and exogenous hormone use are the central focus. A major part of our ongoing work is to improve and document the validity of measurements of dietary and activity variables. The scope of the investigation has also been expanded to include biochemical and genetic determinants of disease risk, with a special strength being the capacity to address potential interactions between genotype and behavioral factors such as diet. The conduct of these large complex studies involves many research assistants, dietitians, programmers, doctoral students, postdoctoral fellows and other faculty members; a substantial amount of my effort is thus involved in coordinating this work and supervising those in training.

D. Report of Teaching

–  –  –

BIBLIOGRAPHY

Original Articles

1. Willett WC, Foulke RA, Robson JRK, Block WD, Perlman LV. Health and nutrition in Michigan Indians. Mich Med 1970;69:305-11.

2. Sinclair MC, Willett WC. The misdiagnosis of chronic constrictive pericarditis. East Afr Med J l976;53:573.

3. Willett WC, Rodocjec V. Urinary tract pathogens and sensitivities in Dar es Salaam. East Afr Med J 1976;53:685.

4. Bura M, Willett WC. The first outbreak of trichinosis in Tanzania. East Afr Med J 1977;54:185-93.

5. Willett WC, Kilama WL, Kihamia CM. Ascaris and growth rates: a randomized trial of treatment. Am J Public Health 1979;69:987-91.

6. Hennekens CH, Willett WC, Rosner B, Cole DS, Mayrent SL. Effects of beer, wine, and liquor in coronary deaths. JAMA 1979;242:1973-4.

7. Willett WC, Hennekens CH, Siegel AJ, Adner MM, Castelli WP. Alcohol and HDL cholesterol among marathon runners. N Engl J Med 1980;303:1159-61.

8. Willett WC, Hennekens CH, Bain C, Rosner B, Speizer FE. Cigarette smoking and non-fatal myocardial infarction in women. Am J Epidemiol 1981;113:575-82.

9. Willett WC, Bain C, Hennekens CH, Rosner B, Speizer FE. Oral contraceptives and risk of ovarian cancer. Cancer 1981;48:1684.

10. Willett WC, Sampson L, Bain C, Rosner B, Hennekens CH, Witschi J, Speizer FE. Vitamin supplement use among registered nurses. Am J Clin Nutr 1981;34:1121-5.

11. Bain C, Willett W, Hennekens CH, Rosner B, Belanger C, Speizer FE. Use of post-menopausal hormones and risk of myocardial infarction. Circulation 1981;64:42-6.

12. Bain C, Willett W, Rosner B, Speizer FE, Belanger C, Hennekens CH. Early age at first birth and decreased risk of breast cancer. Am J Epidemiol 1981;114:705-9.

13. Bain C, Hennekens CH, Speizer FE, Rosner B, Willett W, Belanger C. Oral contraceptive use and malignant melanoma. J Natl Cancer Inst 1982;68:537-9.

14. Willett WC, Hennekens CH, Castelli W, Rosner B, Evans D, Taylor J, Kass EH. Cigarette smoking and fasting triglycerides, total cholesterol and HDL cholesterol in women. Am Heart J 1983;105:417-21.

15. Stampfer M, Willett W, Castelli WP, Taylor JO, Fine J, Hennekens CH. The effect of vitamin E on lipids. Am J Clin Path 1983;79:714-16.

16. Willett W, Stampfer M, Bain C, Rosner B, Speizer FE. Cigarette smoking, relative weight, and menopause. Am J Epidemiol 1983;117:651-8.

17. Willett WC, Polk BF, Morris JS, Pressel S, Rosner B, Taylor JO, Schneider K, Hames CG. Prediagnostic serum selenium and risk of cancer. Lancet 1983;2:130-4.

18. Willett WC, Stampfer MJ, Underwood BA, Speizer FE, Rosner B, Hennekens CH. Validation of a dietary questionnaire with plasma carotenoid and alpha-tocopherol levels. Am J Clin Nutr 1983;38:631-9.

19. Willett WC, Stampfer MJ, Underwood BA, Taylor JO, Hennekens CH. Vitamin A, E, and carotene:

Effects of supplementation on their plasma levels. Am J Clin Nutr 1983;38:559-66.

20. Morris JS, Stampfer MJ, Willett WC. Dietary selenium in humans: toenails as an indicator. Biol Trace Elem Res 1983;5:529-37.

21. Lipnick RJ, Speizer FE, Bain C, Willett W, Rosner B, Stampfer M, Belanger C, Hennekens CH. A case-control study of risk indicators among women with premenopausal and early postmenopausal breast cancer. Cancer 1984;53:1020-4.

22. Willett WC, Polk BF, Underwood BA, Stampfer MJ, Pressel S, Rosner B, Taylor JO, Schneider K, Hames CG. Relation of serum vitamin A and E and carotenoids to the risk of cancer. N Engl J Med 1984;310:430-4.

23. Willett WC, Polk BF, Underwood BA, Hames CG. The HDFP Study of serum retinol, retinol-binding protein, total carotenoids, and cancer risk: a summary. J Natl Cancer Inst l984;73:l459-62.

24. Willett WC, Stampfer MJ, Underwood BA, Sampson LS, Hennekens CH, Wallingford JC, Cooper L, Hsieh C, Speizer FE. Vitamin A supplementation and plasma retinol levels: a randomized trial among women. J Natl Cancer Inst l984;73:l445-8.

25. Hennekens CH, Speizer FE, Lipnick R, Rosner B, Bain C, Belanger C, Willett W, Stampfer MJ, Peto R.

Oral contraceptive use and breast cancer: a case-control study. J Natl Cancer Inst l984;72:39-42.

26. Stampfer MJ, Willett WC, Speizer FE, Dysert DC, Lipnick R, Rosner B, Hennekens CH. Test of the National Death Index. Am J Epidemiol l984;ll9:837-9.

27. Cramer DW, Welch WR, Hutchison AB, Willett W, Scully RE. Dietary animal fat in relation to ovarian cancer risk. Obstet Gynecol l984;63:837-8.

28. Willett WC, Polk BF, Underwood BA, Hames CG. Hypertension detection and follow-up program study of serum retinol, retinol-binding protein, total carotenoids, and cancer risk: a summary. J Natl Cancer Inst 1984;73:1459-62.

29. Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE.

Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol l985;l22:5l-65.

30. Willett WC, Browne ML, Bain C, Lipnick RJ, Stampfer MJ, Rosner B, Colditz GA, Hennekens CH, Speizer FE. Relative weight and risk of breast cancer among premenopausal women. Am J Epidemiol l985;l22:73l-40.

31. Colditz GA, Branch LG, Lipnick RJ, Willett WC, Rosner B, Posner BM, Hennekens CH. Moderate alcohol and decreased risk of cardiovascular mortality in an elderly cohort. Am Heart J l985;l09:886-9.

32. Colditz GA, Branch LG, Lipnick RJ, Willett WC, Rosner B, Posner BM, Hennekens CH. Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population. Am J Clin Nutr l985;4l:32-6.

33. Stampfer MJ, Buring J, Willett W, Rosner B, Eberlein K, Hennekens CH. The 2x2 factorial design: its application to a randomized trial of aspirin and carotene among US physicians. Stat Med l985;4:lll-16.

34. Stampfer MJ, Willett WC, Colditz GA, Rosner B, Speizer FE, Hennekens CH. A prospective study of postmenopausal estrogen and coronary heart disease. N Engl J Med l985;3l3:l044-9.

35. Shapiro C, Cook N, Willett WC, Fajardo I, Koch-Weser D, Bergonzoli G, Belanos O, Guerrero R, Hennekens CH. A case-control study of BCG and childhood tuberculosis in Cali, Columbia. Int J Epidemiol l985;l4:44l-7.

36. Swartz S, Willett WC, Hennekens CH. A randomized trial of the effect of vitamin E on plasma prostacyclin (6-keto PGF1 alpha) levels in healthy adults. Prostaglandins Leukot Med l985;l8:l05-11.

37. Colditz GA, Stampfer MJ, Willett WC, Rosner B, Speizer FE, Hennekens CH. A prospective study of parental history of myocardial infarction and coronary heart disease in women. Am J Epidemiol l986;l23:48-58.

38. Stampfer MJ, Jakubowski JA, Deykin D, Schafer AI, Willett WC, Hennekens CH. Effect of alternate day regular and enteric coated aspirin on platelet aggregation, bleeding time, and thromboxane2 levels in bleeding time blood. Am J Med l986;8l:400-4.

39. Colditz GA, Martin P, Stampfer MJ, Willett WC, Sampson L, Rosner B, Hennekens CH, Speizer FE.

Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study in women. Am J Epidemiol l986;l23:894-900.

40. Lipnick RJ, Buring JE, Hennekens CH, Rosner B, Willett W, Bain C, Stampfer MJ, Colditz GA, Peto R, Speizer FE. Oral contraceptives and breast cancer: a prospective cohort study. JAMA l986;255:58-6l.



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