FREE ELECTRONIC LIBRARY - Dissertations, online materials

Pages:   || 2 |

«A monograph entitled Environmental Health Criteria 160 Ultraviolet Radiation was published in 1994 by the World Health Organization, jointly in ...»

-- [ Page 1 ] --

Health and Environmental Effects of Ultraviolet Radiation

A Scientific Summary of Environmental Health Criteria 160

Ultraviolet Radiation ((WHO/EHG/95.16)


A monograph entitled Environmental Health Criteria 160 "Ultraviolet Radiation" was published in 1994 by the

World Health Organization, jointly in collaboration with the United Nations Environment Programme and the

International Commission on Non-Ionizing Radiation Protection. The monograph was the result of an in-depth

review of the scientific literature and was primarily concerned with the effects of ultraviolet (UV) radiation exposure on human health and the environment. The penultimate draft was subjected to a WHO Task Group for final peer review prior to publication. Such a review was considered particularly timely in view of the consequences of increasing levels of UV at the surface of the earth resulting from depletion of stratospheric ozone.

The purpose of this document is to provide a summarised form of the monograph, allowing the subject to be reviewed by a more general readership, and to update activities that have resulted from the recommendations of the Task Group that reviewed the monograph.

Exposure to UV occurs from both natural and artificial sources. The sun is the principal source of exposure for most people. Solar UV undergoes significant absorption by the atmosphere. With depletion of the stratospheric ozone people and the environment will be exposed to higher intensities of UV. The consequences of this added UV exposure are considered so serious that it was a major topic for discussion at the World Environment Conference, held in Rio de Janeiro in 1992. In Agenda 21, adopted by the Conference, it was specifically recommended to "undertake, as a matter of urgency, research on the effects on human health of the increasing ultraviolet radiation reaching the earth's surface as the consequence of depletion of the stratospheric ozone layer." It is this issue that underscores the current need to better understand the potential health and environmental risks of UV exposure. INTERSUN, global UV project, is WHO's response to the need to disseminate information about the health and environmental hazards of excessive UV exposure. INTERSUN has developed a document entitled "UV Protective Measures" in response to the need to educate the public and workers on measures they can take to reduce their UV exposure, and has been involved in the development of a Solar UV Index, an index related to daily UV exposure, reported with the news and weather, that facilitates a continuing educational process about possible health effects and measures to reduce UV exposure. More details on these programmes are given at the end of this text.

Summary of the major health concerns Skin cancer and cataracts are important public health concerns. The social cost of these diseases, such as death, disfigurement and blindness, can be overwhelming both in terms of human suffering and the financial burden.

Solar UV exposure is known to be associated with various skin cancers, accelerated skin aging, cataract of the lens of the eye and other eye diseases, and possibly has an adverse effect a person's ability to resist infectious diseases. Most of these health concerns could be avoided by reducing exposure to solar UV.

The United Nations Environment Programme has estimated that over 2 million non-melanoma skin cancers and 200,000 malignant melanomas occur globally each year. In the event of a 10% decrease in stratospheric ozone, with current trends and behaviour, an additional 300,000 non-melanoma and 4,500 melanoma skin cancers could be expected world-wide.

Some 12 to 15 million people in the world are blind because they have cataracts. WHO has estimated that up to 20% of cataracts or 3 million per year could be due to UV exposure to the eye. It has been estimated that for each 1% sustained decrease in stratospheric ozone there would be an increase of 0.5% in the number of cataracts caused by solar UV (van der Leun et al 1989). In the United States alone, it costs the US Government $US 3.4 billion for 1.2 million cataract operations per year. Substantial savings in cost to health care can be made by prevention or delay in the onset of cataracts.

Ultraviolet radiation

UV is one of the non-ionizing radiations in the electromagnetic spectrum and lies within the range of wavelengths 100 nm to 400 nm (see figure 1). The short wavelength limit of the UV region is often taken as the boundary between the ionizing radiation spectrum (wavelengths 100 nm) and the non-ionizing radiation spectrum. UV can be classified into UVA (315 - 400 nm), UVB (280 - 315 nm) and UVC (100 - 280 nm) regions, although other conventions for UVA, UVB and UVC wavelength bands are in use.

Most artificial sources of UV, except for lasers, emit a spectral continuum of UV containing characteristic peaks, troughs and lines. These sources include various lamps used in medicine, industry, commerce, research and the home.

Figure 1: Solar optical emissions before and after absorption by the atmosphere.

Since UV is normally absorbed over a surface it can be measured as a radiant exposure, the incident UV energy divided by the receptor surface area in joules per square metre (J m-2). UV can also be measured as an irradiance, the incident power divided by the receptor surface area in watts per square metre (W m-2).

Biological effectiveness of UV

UV-induced biological effects depend on the wavelengths of the radiation emitted by the source. Thus, for a proper determination of hazard it is necessary to have information on the spectral (range of wavelength) emissions. These consist of spectral irradiance (W m-2 nm-1) measurements from the source. The total irradiance (W m-2) is obtained by summing over all wavelengths emitted. The biological or hazard weighted irradiance (W m-2 effective), commonly called the effective UV irradiance or dose rate (exposure), is determined by multiplying the spectral irradiance at each wavelength by the biological or hazard weighting factor (which quantifies the relative efficacy at each wavelength for causing the effect) and summing over all wavelengths. Such factors or weighting functions are obtained from action spectra.

Action Spectrum and Minimum Erythemal Dose

An action spectrum is a graph that provides information on the effectiveness of the UV wavelengths in producing a biological effect, eg erythema. It is the reciprocal of the radiant exposure required to produce the given effect at each wavelength. Figure 2 depicts the ICNIRP-CIE action spectrum for erythema. All the data in such curves are normalized to the most effective wavelength(s). By summing the biologically effective irradiance over the exposure period, the biologically effective radiant exposure (J m-2 effective) can be calculated.

For UV induced erythema, the action spectrum adopted by the International Commission on Non-Ionizing Radiation Protection (ICNIRP), International Commission on Illumination (CIE), the International Electrotechnical Commission (IEC) and various national bodies, is a composite curve obtained by statistical analysis of many research results on the minimum radiant exposure of UV at different wavelengths necessary to just cause erythema.

Figure 2: Action spectrum for erythema.

The most commonly used quantity for describing the erythemal potential of an exposure to UV is the number of minimum erythemal doses (MEDs) represented by the exposure. An MED is the radiant exposure of UV that produces a just noticeable erythema on a previously unexposed skin. It corresponds to a radiant exposure of monochromatic radiation at the maximum spectral efficacy for erythema (around 300 nm) of approximately 150 to 2000 J m-2 effective, depending on skin type. Values of 200 - 300 J m-2 effective are commonly used as the value of 1 MED for comparative safety purposes for white skin.

Cellular and Molecular Studies

To produce any change, UV must be absorbed by a biological molecule. This involves absorption of a single photon by the molecule and the production of an excited state in which one electron of the absorbing molecule is raised to a higher energy level. The primary products caused by UV exposure are generally reactive species or free radicals which form extremely quickly but which can produce effects that can last for hours, days or even years. DNA is the most critical target for damage by UVB and UVC. Figure 3 indicates the formation of pyrimidine dimers in DNA. While a considerable amount of knowledge is available concerning the interaction of UV with nucleic acids, controversy exists as to which lesion constitutes the most important type of pre-mutagenic damage.

Cell death, chromosome changes, mutation and morphological transformations are observed after UV exposure of procaryotic and eucaryotic cells. Many different genes and several viruses (including HIV) are activated by UV exposure. The genes activated by UVB and UVC are different from those activated by UVA. Studies of DNA repair defective disorders have clearly established a link between UV induced DNA damage in skin and various types of cancer.

Animal Studies Skin cancer Solar UV exposure has been shown to produce cancers in domestic and food animals. In experimental animals UV causes predominantly squamous cell carcinomas (SCCs). UVB is most effective at producing SCCs, although they are produced by UVA but at much higher intensities, similar to the levels needed for erythema and tanning. The effectiveness of UVC is unknown except at one wavelength (254 nm). At this wavelength the effectiveness is less than UVB.

Melanomas are much less common and only two animal models have been found for induction of melanoma by UV alone. An initial action spectrum determined for a type of hybrid fish indicates a peak in the UVB range but also shows a high level of effectiveness in the UVA. Basal cell carcinomas are rare in animals.

Immune response

Exposure to suberythemal doses of UV have been shown to exacerbate a variety of infections in rodent models.

UV affects infections both at the site of exposure and at distant sites. Recent work indicates that systemic infections without skin involvement may be affected. Enhanced susceptibility appears to result from T-helper cell activity. The mechanisms associated with this suppression appear to be the same as those identified with suppression to contact and delayed type hypersensitivity responses. Suppression of these immune responses appears to be mediated by release of soluble mediators from UVB exposed skin which alters the antigen presentation by Langerhans and other cells so that they fail to activate TH1 cells. The resulting immune suppression is antigen specific, can occur regardless of whether or not antigen is applied at the site of exposure, and is relatively long lasting. UV exposure also prevents the development of protection immunity to a variety of infections in mice and rats.

Effects on the eye

Many studies in experimental animals have demonstrated that UV exposure can cause both acute and delayed effects such as cataract, photokeratitis, damage to the corneal epithelium and various retinal effects. Studies of photochemical retinal injury in aphakic monkeys have shown that the retina is six times more vulnerable to photochemical damage from UV than the visible wavelengths.

Health Effects on Humans Skin The degree of damage that UV produces in skin will depend on the incident intensity and wavelength content (UVA or UVB), and on the depth of penetration of these wavelengths into the skin (see figure 4). Acute effects on the skin consist of solar erythema, "sunburn", which, if severe enough, may result in blistering and destruction of the surface of the skin with secondary infection and systemic effects, similar to those resulting from a first or second degree heat burn. Although UVC is very efficiently absorbed by nucleic acids, the overlying dead layers of skin absorb the radiation to such a degree that there is only mild erythema and, usually, no late sequelae, even after repeated exposures. Much less is known about the biological effects of UVA. However, doses of UVA, which alone may not show any biological effect, can, in the presence of certain environmental, consumer and medicinal chemical agents, Figure 3: Depth of penetration of UV into the skin.

Chronic skin changes due to UV consist of skin cancer (both melanoma and non-melanocytic), benign abnormalities of melanocytes (freckles, melanocytic naevi and solar or senile lentigines), and a range of other chronic injuries resulting from UV exposure to keratinocytes, blood vessels and fibrous tissue, often described as "photoaging" (solar elastosis). The much increased rates of skin cancer in patients with xeroderma pigmentosum, who have a deficiency in the capacity to repair UV-induced DNA damage, suggest that direct UV damage of the DNA may be a step in the cause of these cancers. This suggestion has also been supported by the observation of UV specific mutations of the p53 tumour suppressor gene in a proportion of patients with non-melanocytic skin cancer. Oxidative and immune suppressant effects may also contribute to the capacity of UV to cause skin cancers.

Cancer of the lip is much more common in fair than dark skin populations and is associated with outdoor work.

However possible confounding with tobacco and alcohol use has not been adequately controlled in any study, and so it is not possible at present to associate directly solar UV exposure in the cause of this cancer.

Strong epidemiological evidence exists that sun exposure causes cutaneous melanoma and non-melanocytic skin cancer. Their incidence is less in darker than light skin groups living in the same geographical area. Risk of skin cancer decreases with increasing pigmentation. The anatomical site most seen for squamous cell carcinoma (SCC) is the head and neck, areas most exposed to the sun. Incidence of both melanoma and non-melanocytic skin cancer are increased in areas of high ambient solar UV radiation.

The worldwide incidence of malignant melanoma has continued to increase. Cutaneous melanoma is the result of neoplastic transformation of melanocytes, the pigment producing cells in the epidermis. Four basic categories of melanoma have been identified in humans: superficial spreading melanoma, nodular melanoma, lentigo malignant melanoma (also known as Hutchinson's melanotic freckle), and unclassified melanoma.

Pages:   || 2 |

Similar works:

«POSTER PRESENTATIONS – TUESDAY, MAY 24, 2016 #1 ORAL GRANULOCYTIC SARCOMA AS FIRST MANIFESTATION OF ACUTE MYELOMONOCYTIC LEUKEMIA. A CASE REPORT AND REVIEW OF THE LITERATURE. S Titsinides, Dental School, U. of Athens, Greece, N Nikitakis, Dental School, U. of Athens, Greece M Georgaki, Dental School, U. of Athens, Greece D Maltezas, First Propaedeutic Department of Internal Medicine, Medical School, U. of Athens, Greece P Panayotidis, First Propaedeutic Department of Internal Medicine,...»

«Strukturelle Charakterisierung von pGolemi, einem hochaffinen, synthetischen Mena EVH1-Liganden Dissertation zur Erlangung des Doktorgrades Dr. rer. nat. des Fachbereichs Biologie und Geografie an der Universität Duisburg-Essen Campus Essen vorgelegt von Nina Malaika Link geboren in Buchen (Odenwald) Januar 2009 Die der vorliegenden Arbeit zu Grunde liegenden Experimente wurden in der Abteilung Strukturelle und Medizinische Biochemie am Zentrum für Medizinische Biotechnologie der Universität...»

«REPORT 8/16 Hazardous chemical substances in textiles – proposals for risk management measures Report from a government assigment kemikalieinspektionen.se The Swedish Chemicals Agency is supervisory authority under the Government. We work in Sweden, the EU and internationally to develop legislation and other incentives to promote good health and improved environment. We monitor compliance of applicable rules on chemical products, pesticides and substances in articles and carry out...»

«28th EACTS Annual Meeting Milan, Italy 11 15 October 2014 www.eacts.org FinalFinal Programme Programme www.covidien.com Covidien Surgical Solutions in Thoracic Surgery Endo GIA™ Radial Reload with Tri‑Staple™ Technology Access, with potential to spare tissue in Thoracic Surgery1 • Avoid crossing staple lines • Create greater distal margins • Save healthy lung tissue LigaSure™ Maryland Jaw Open/Laparoscopic Sealer/Divider Reach for Perfection • Efficient • Versatile •...»

«Mark Matthews mark.matthews@tcd.ie www.aplayspace.com Education PhD in Computer Science (Human-Computer Interaction) Trinity College Dublin, 2009 Thesis: ‘The design of systems to engage adolescents in professional mental health services’ Supervisors: Dr. Gavin Doherty (TCD), Dr. John Sharry (Mater Hospital) Software: designed and developed three innovative mental health technological tools that are still in clinical use, including the award-winning Personal Investigator game. Dissemination...»

«APPENDIX C: IL FOUNDATIONS 50 Foundations in Illinois 1) Abbott Laboratories Fund Dept. 379, Bldg. Apt. 6D 100 Abbott Park Rd. Abbott Park, IL 60064-3500 Telephone: (847) 937-7075 Contact: Cindy Schwab, V.P. URL: http://www.abbott.com/community/lab_fund.html Donor(s): Abbott Laboratories. Type of grantmaker: Company-sponsored foundation. Background: Incorporated in 1951 in IL. Purpose and activities: In the area of education, support for institutions whose programs and services possess the...»

«297 Ga. 810 FINAL COPY S15A0795. WARREN v. THE STATE. NAHMIAS, Justice. Jesse James Warren has been indicted on four counts of murder and many additional charges in connection with a mass shooting at a Penske Trucking Company location in Cobb County on January 12, 2010, in which four victims were killed and a fifth victim was paralyzed. The State has given notice of its intent to seek the death penalty. On March 4, 2013, Warren filed a special plea of mental incompetence to stand trial. See...»

«Ellen G. Levine, Ph.D., M.P.H. 1 Curriculum Vitae Ellen Gail Levine, Ph.D., M.P.H. P.O. Box 2278 Castro Valley, California Phone: 510-889-7494 California License No: PSY 12356 Present Position 2000 to present: Owner Levine Biopsychosocial Research Consulting. Levineresearchconsulting.com 2007 to present: Contributing Faculty Member, Department of Psychology, Health Psychology Program, Walden University 2005 to present: Outside dissertation reviewer, California Institute of Integral Studies...»

«Title Oral health status of asthmatic preschoolers in Hong Kong Chan, BKL; Lui, KC; Chan, YH; Cheung, SS; Hung, YW; Lau, Author(s) KHY; Man, WHC; Wu, KW Chan, BKL, Lo, ECM, Gao, X, et al. Oral health status of Citation asthmatic preschoolers in Hong Kong. Hong Kong: Community Health Project, 2010 Issued Date 2010 URL http://hdl.handle.net/10722/65417 Rights Creative Commons: Attribution 3.0 Hong Kong License Dental Public Health Oral health status of asthmatic preschoolers in Hong Kong ISSN...»

«TEXAS DEPARTMENT OF STATE HEALTH SERVICES Region 8 Update Fall 2013 FROM THE REGIONAL MEDICAL DIRECTOR Dear Region 8 Employees, The Department of State Health Services is currently undergoing a Sunset Review. This legislatively mandated process involves a commission reviewing the mission and the work of our agency to determine if it is still relevant and needed. Our division, Regional and Local Health Services, presented to the Commission on October 21, including slides specific to our work in...»

«Management of Astigmatism in Cataract Surgery Jonathan B. Rubenstein, MD Vice-Chairman and Deutsch Family Professor of Ophthalmology Director of Cornea and Refractive Surgery Rush University Medical Center Financial Disclosure Alcon Consultant Allergan Consultant Bausch and Lomb Consultant Introduction The goal of cataract surgery in the year 2012 is to achieve emmetropia or balance with the fellow eye.1. The spherical component is calculated using IOL Master or LensStar Water bath ultrasound...»

«Regional Health Meetings in the Pacific and their Impact on Health Governance Joel Negin, Chris Morgan, and Rob Condon As a result of the increased number of regional health meetings in the Pacific region, senior health professionals in the Pacific have expressed concern about the costs, effectiveness and legitimacy of these gatherings. Our review of health meetings in the Pacific identified 52 meetings that take place as regular gatherings of regional governance mechanisms and 14 one-off...»

<<  HOME   |    CONTACTS
2016 www.dissertation.xlibx.info - Dissertations, online materials

Materials of this site are available for review, all rights belong to their respective owners.
If you do not agree with the fact that your material is placed on this site, please, email us, we will within 1-2 business days delete him.