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«Department of Epidemiology Office Address: UNC Gillings School of Global Public Health University of North Carolina at Chapel Hill ...»

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DATE PREPARED: Jan 20th, 2011


Maurice Alan Brookhart


Department of Epidemiology

Office Address:

UNC Gillings School of Global Public Health

University of North Carolina at Chapel Hill

McGavran-Greenberg, CB # 7435

Chapel Hill, NC 27599-7435


2002 Ph.D. (Biostatistics), University of California, Berkeley 1996 M.A. (Biostatistics), University of California, Berkeley 1994 M.A.M.S (Applied Math), University of Georgia 1990 B.A., University of North Carolina, Chapel Hill


Academic Appointments 2010- Adjunct Associate Professor, Department of Medicine, School of Medicine, UNC Chapel Hill, Chapel Hill, NC 2009- Associate Professor, Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 2008-2009 Assistant Professor of Medicine, Harvard Medical School, Boston MA 2003-2008 Instructor in Medicine, Harvard Medical School, Boston, MA Other Professional Positions and Major Visiting Appointments 2010- Fellow, Cecil G. Sheps Center for Health Services Research 2009 Consultant, Kaiser Permanente Center for Health Research 2008- Consultant, World Health Information Science Consultants 2009-2010 Director of Research Methods, Division of Pharmacoepidemiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 2008-2009 Consultant, Chronic Disease Research Group, Minneapolis, MN 2008- Member, Interfaculty Initiative on Medications and Society, Harvard University 2007-2008 Consultant, McKesson Health Solutions 2005-present Consultant and External Member, Working Group in Pharmacoepidemiology, Therapeutics Initiative, University of British Columbia at Vancouver, Vancouver, BC 2004-2005 Consultant, World Health Organization, Geneva, Switzerland 2003- Biostatistician, Brigham and Women's Hospital, Boston, MA 1997-2003 Statistical Consultant, Meridian Software, Inc., Raleigh, NC AWARDS 1995 Regents Fellowship, University of California at Berkeley 1994-1994 Phi Kappa Phi, University of Georgia 1993-1993 Beta Gamma Sigma, University of Georgia 1992-1994 Regents Award, University of Georgia


Refereed Papers/Articles

1. Funk MJ, Westreich D, Wiesen C, Stürmer T, Brookhart MA, Davidian M.

Doubly Robust Estimation of Causal Effects. Pharmacoepidemiol Drug Saf. 2011 [Epub ahead of print]

2. Brookhart MA, Bradbury BD, Avorn J, Schneeweiss S, Winkelmayer WC. The Effect of Altitude Change on Anemia Treatment Response in Hemodialysis Patients. Am J Epidemiol. 2011 Feb 23. [Epub ahead of print]

3. Brookhart MA, Solomon DH, Glynn RJ, Ridker PM. Effect of Rosuvastatin on Hemoglobin Levels in Patients With Anemia and Low-Grade Inflammation: A Post Hoc Analysis of the JUPITER Trial. J Clin Pharmacol. 2010 Dec 28

4. Solomon DH, Brookhart MA, Tsao P, Sundaresan D, Andrade SE, Mazor K, Yood R.

Predictors of very low adherence with medications for osteoporosis: towards development of a clinical prediction rule. Osteoporos Int. 2010 Sep 29. [Epub ahead of print]

5. Cadarette SM, Solomon DH, Katz JN, Patrick AR, Brookhart MA.

Adherence to osteoporosis drugs and fracture prevention: no evidence of healthy adherer bias in a frail cohort of seniors. Osteoporos Int. 2011 Mar;22(3):943-54.

6. Winkelmayer WC, Stedman MR, Pogantsch M, Wieninger P, Bucsics A, Asslaber M, Bauer R, Burkhardt T, Schautzer A, Brookhart MA; Pharmacoeconomics Advisory Council of the Main Association of Austrian Sickness Funds. Guideline-conformity of initiation with oral hypoglycemic treatment for patients with newly therapy-dependent type 2 diabetes mellitus in Austria. Pharmacoepidemiol Drug Saf. 2011 Jan;20(1):57-65.

7. Shrank WH, Choudhry NK, Fischer MA, Avorn J, Powell M, Schneeweiss S, Liberman JN, Dollear T, Brennan TA, Brookhart MA. The epidemiology of prescriptions abandoned at the pharmacy. Ann Intern Med. 2010 Nov 16;153(10):633-40.

8. Cutrona SL, Choudhry NK, Stedman M, Servi A, Liberman JN, Brennan T, Fischer MA, Brookhart MA, Shrank WH. Physician effectiveness in interventions to improve cardiovascular medication adherence: a systematic review. J Gen Intern Med. 2010 Oct;25(10):1090-6.

9. Choudhry NK, Fischer MA, Avorn J, Schneeweiss S, Solomon DH, Berman C, Jan S, Liu J, Lii J, Brookhart MA, Mahoney JJ, Shrank WH. At Pitney Bowes, value-based insurance design cut copayments and increased drug adherence. Health Aff (Millwood).

2010 Nov;29(11):1995-2001.

10. Shrank WH, Choudhry NK, Agnew-Blais J, Federman AD, Liberman JN, Liu J, Kesselheim AS, Brookhart MA, Fischer MA. State generic substitution laws can lower drug outlays under medicaid. Health Aff (Millwood). 2010: 29(7):1383-90.

11. Brookhart MA, Stürmer T, Glynn RJ, Rassen JA, Schneeweiss S. Confounding control in healthcare database research: challenges and potential approaches. Med Care, 2010 Jun; S114-20.

June 18, 2009 2

12. Cadarette SM, Solomon DH, Katz JN, Patrick AR, Brookhart MA. Adherence to osteoporosis drugs and fracture prevention: no evidence of healthy adherer bias in a frail cohort of seniors. Osteoporosis Int 2010; in press.

13. Patrick AR, Brookhart MA, Losina E, Schousboe JT, Cadarette SM, Mogun H, Solomon DH. The complex relation between bisphosphonate adherence and fracture reduction. J Clin Endocrinol Metab. 2010, in press.

14. Kesselheim AS, Stedman MR, Bubrick EJ, Gagne JJ, Misono AS, Lee JL, Brookhart

MA, Avorn J, Shrank WH. Seizure outcomes following the use of generic versus brandname antiepileptic drugs: a systematic review and meta-analysis. Drugs. 2010:


15. Brookhart MA, Schneeweiss S, Avorn J, Bradbury B, Liu J, Winkelmayer W.

Comparative mortality risk of anemia management practices in end-stage renal disease.

JAMA. 2010; 303(9): 857-64.

16. Brookhart MA, Rassen JA, Schneeweiss S. Instrumental variable methods in comparative safety and effectiveness research. Pharmacoepidemiol Drug Saf. 2010 Mar 30. [Epub ahead of print]

17. Winkelmayer WC, Asslaber M, Bucsics A, Burkhardt T, Schautzer A, Wieninger P, Pogantsch M, Brookhart MA. Impact of reimbursement changes on statin use among patients with diabetes in Austria. Wien Klin Wochenschr. 2010 Feb;122(3-4):89-94.

18. Chan DC, Shrank WH, Cutler D, Jan S, Fischer MA, Liu J, Avorn J, Solomon D, Brookhart MA, Choudhry NK. Patient, physician, and payment predictors of statin adherence. Med Care. 2010;48(3):196-202.

19. Solomon DH, Gleeson T, Iversen M, Avorn J, Brookhart MA, Lii J, Losina E, May F, Patrick A, Shrank WH, Katz JN. A blinded randomized controlled trial of motivational interviewing to improve adherence with osteoporosis medications: design of the OPTIMA trial. Osteoporos Int. 2010 Jan;21(1):137-44.

20. Bradbury BD, Brookhart MA, Winkelmayer WC, Critchlow CW, Kilpatrick RD, Joffe MM, Feldman HI, Acquavella JF, Wang O, Rothman KJ. Evolving statistical methods to facilitate evaluation of the causal association between erythropoiesis-stimulating agent dose and mortality in nonexperimental research: strengths and limitations. Am J Kidney Dis. 2009 Sep;54(3):554-60.

21. Bradbury BD, Do TP, Winkelmayer WC, Critchlow CW, Brookhart MA. Greater Epoetin alfa (EPO) doses and short-term mortality risk among hemodialysis patients with hemoglobin levels less than 11 g/dL. Pharmacoepidemiol Drug Saf. 2009;18(10):932-40.

22. Choudhry NK, Shrank WH, Levin RL, Lee JL, Jan SA, Brookhart MA, Solomon DH.

Measuring concurrent adherence to multiple related medications. Am J Manag Care.

2009; 15(7):457-64.

23. Stedman MR, Gagnon DR, Lew RA, Solomon DH, Brookhart MA. A SAS Macro for Cluster-Randomized Permutation Testing. Computer Methods and Programs in Biomedicine, 2009; 95(1):89-94.

24. Schneeweiss S, Rassen J, Avorn J, Mogun H, Brookhart MA. High dimensional proxy adjustment via propensity scores. Epidemiology, 2009; 20(4):512-22.

25. Cadarette SM, Katz JN, Brookhart MA, Stürmer T, Stedman MR, Levin R, Solomon DH.

Comparative gastrointestinal safety of weekly oral bisphosphonates. Osteoporos Int., Osteoporos Int. 2009; 20(10):1735-47.

26. Rassen JA, Brookhart MA, Glynn RJ, Mittleman MA, Schneeweiss S. Instrumental variables I: instrumental variables exploit natural variation in nonexperimental data to estimate causal relationships. J Clin Epidemiol. 2009 Dec;62(12):1226-32.

June 18, 2009 3

27. Rassen JA, Brookhart MA, Glynn RJ, Mittleman MA, Schneeweiss S. Instrumental variables II: instrumental variable application in 25 variations, the physician prescribing preference generally was strong and reduced covariate imbalance. J Clin Epidemiol.

2009 Dec; 62(12):1233-41.

28. Shrank WH, Choudhry NK, Solomon DH, Snedden TM, Lee TH, Glynn RJ, Brown TV, Jolda C, Spetman M, Brookhart MA, Schneeweiss S, Avorn J. Rationale and design of the Study Assessing the Effect of Cardiovascular Medications Provided as Low-cost, Evidence-based Generic Samples (SAMPLES) trial. Am Heart J. 2009;157(4):613-9.

29. Dormuth C, Patrick AR, Wright JM, Brookhart MA. Statin adherence and risk of accidents: a cautionary tale. Circulation. 2009 119(15):2051-9.

30. Winkelmayer WC, Liu J, Brookhart MA. The effect of altitude on mortality in ESRD.

JAMA. 2009;301(5):508-12.

31. Shrank WH, Gleason PP, Canning C, Walters C, Heaton AH, Jan S, Patrick A, Brookhart MA, Schneeweiss S, Solomon DH, Avorn J, Choudhry NK. Can Improved Prescription Medication Labeling Influence Adherence to Chronic Medications? An Evaluation of the Target Pharmacy Label. J Gen Intern Med. 2009; 24(5):570-8

32. Gellad WF, Choudhry NK, Friedberg MW, Brookhart MA, Haas JS, Shrank WH.

Variation in Drug Prices at Pharmacies: Are Prices Higher in Poorer Areas? Health Serv Res. 2009; 44(2 Pt 1):606-17.

33. Schneeweiss S, Setoguchi S, Brookhart MA, Kaci L, Wang PS. Assessing Residual Confounding of the Association between Antipsychotic Medications and Risk of Death using Survey Data. CNS Drugs. 2009; 23(2):171-80.

34. Rassen JA, Schneeweiss S, Glynn RJ, Mittleman MA, Brookhart MA. Instrumental variable analysis for estimation of treatment effects with dichotomous outcomes. Am J Epidemiol. 2009; 169(3):273-84

35. Kesselheim AS, Misono AS, Lee JL, Stedman MR, Brookhart MA, Choudhry NK, Shrank WH. Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: a systematic review and meta-analysis. JAMA. 2008;


36. Fischer MA, Vogeli C, Stedman M, Ferris T, Brookhart MA, Weissman JS. Effect of electronic prescribing with formulary decision support on medication use and cost. Arch Intern Med. 2008;168(22):2433-9.

37. Kulik A, Brookhart MA, Levin R, Ruel M, Solomon DH, Choudhry NK. Impact of statin use on outcomes after coronary artery bypass graft surgery. Circulation.


38. Brookhart MA, Rothman KJ. Simple estimators of the intensity of seasonal occurrence.

BMC Med Res Methodol. 2008;8(1):67.

39. Stedman MR, Gagnon DR, Lew RA, Solomon DH, Brookhart MA. An evaluation of statistical approaches for analyzing physician-randomized quality improvement interventions. Contemp Clin Trials. 2008;29(5):687-95.

40. Brookhart MA, Schneeweiss S, Avorn J, Bradbury BD, Rothman KJ, Fischer M, Mehta J, Winkelmayer WC. The effect of altitude on dosing and response to erythropoietin in ESRD. J Am Soc Nephrol. 2008;19(7):1389-95.

41. Choudhry NK, Brennan T, Toscano M, Spettell C, Glynn RJ, Rubino M, Schneeweiss S, Brookhart MA, Fernandes J, Mathew S, Christiansen B, Antman EM, Avorn J, Shrank WH. Rationale and design of the Post-MI FREEE trial: a randomized evaluation of firstdollar drug coverage for post-myocardial infarction secondary preventive therapies. Am Heart J. 2008;156(1):31-6.

June 18, 2009 4

42. Cadarette SM, Katz JN, Brookhart MA, Sturmer T, Stedman MR, Solomon DH. Relative effectiveness of osteoporosis drugs for preventing nonvertebral fracture. Ann Intern Med.


43. Goodson NJ, Brookhart MA, Symmons DP, Silman AJ, Solomon DH. Non-Steroidal Anti-Inflammatory drug use does not appear to be associated with increased cardiovascular mortality in patients with inflammatory polyarthritis: Results from a primary care based inception cohort of patients. Ann Rheum Dis. 2008; 68(3):367-72.

44. Bowry AD, Brookhart MA, Choudhry NK. Meta-analysis of the efficacy and safety of clopidogrel plus aspirin as compared to antiplatelet monotherapy for the prevention of vascular events. Am J Cardiol. 2008;101(7):960-6.

45. Setoguchi S, Schneeweiss S, Brookhart MA, Glynn RJ, Cook EF. Evaluating uses of data mining techniques in propensity score estimation: a simulation study.

Pharmacoepidemiol Drug Saf. 2008; 17(6):546-55.

46. Cadarette SM, Katz JN, Brookhart MA, Levin R, Stedman MR, Choudhry NK, Solomon DH. Trends in drug prescribing for osteoporosis after hip fracture, 1995-2004. J Rheumatol. 2008;35(2):319-26.

47. Dormuth CR, Maclure M, Glynn RJ, Neumann P, Brookhart MA, Schneeweiss S.

Emergency hospital admissions after income-based deductibles and prescription copayments in older users of inhaled medications. Clin Ther. 2008;30P1:1038-1050.

48. van Wijk BL, Shrank WH, Klungel OH, Schneeweiss S, Brookhart MA, Avorn J. A crossnational study of the persistence of antihypertensive medication use in the elderly. J Hypertens. 2008;26(1):145-153.

49. Brookhart MA, Schneeweiss S. Preference-based instrumental variable methods for the estimation of treatment effects. International Journal of Biostatistics. 2007;3(1):14.

50. Wang PS, Schneeweiss S, Setoguchi S, Patrick A, Avorn J, Mogun H, Choudhry NK, Brookhart MA. Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications. J Clin Psychopharmacol.


51. Solomon DH, Katz JN, Carrino JS, Levin R, Brookhart MA. Percutaneous vertebroplasty among low-income Medicare beneficiaries. Spine. 2007;32(25):2910-4.

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