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«Read all of this leaflet carefully before you start taking this medicine. - Keep this leaflet. You may need to read it again. - If you have any ...»

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Timolol 0.25% w/v Eye Drops Solution

Timolol 0.5% w/v Eye Drops Solution

Timolol maleate

Read all of this leaflet carefully before you start taking this medicine.

- Keep this leaflet. You may need to read it again.

- If you have any further questions, ask your doctor, pharmacist or nurse.

- This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.

- If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet..

In this leaflet:

1. What Timolol is and what it is used for

2. Before you use Timolol

3. How to use Timolol

4. Possible side effects

5. How to store Timolol

6. Contents of the pack and other information

1. What Timolol is and what it is used for Timolol Eye Drops contain a substance called timolol which belongs to a group of medicines called beta-blockers. Timolol lowers the pressure in your eye(s). It is used to treat glaucoma, when the pressure in the eye is raised.

2. Before you use Timolol

Do not use Timolol Eye Drops:

 if you are allergic to timolol maleate, beta-blockers or any of the other ingredients  if you have now or have had in the past respiratory problems such as severe asthma, severe chronic obstructive bronchitis (severe lung condition which may cause wheeziness, difficulty in breathing and/or long-standing cough).

 if you have a slow heart beat, heart failure or disorders of heart rhythm (irregular heart beats).

If you are not sure whether you should use Timolol Eye Drops talk to your doctor or pharmacist.

Take special care with Timolol Eye Drops:

Before you use this medicine, tell your doctor if you have now or have had in the past.

 coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart failure, low blood pressure,  disturbances of heart rate such as slow heart beat.

 breathing problems, asthma or chronic obstructive pulmonary disease  poor circulation disease (such as Raynaud’s disease or Raynaud’s syndrome)  diabetes as Timolol may mask signs and symptoms of low blood sugar  overactivity of the thyroid gland as Timolol may mask signs and symptoms  Contact lenses. These should be removed before treatment with Timolol and not put back into your eyes until 15 minutes after using the eye drops.

Tell your doctor before you have an operation that you are using Timolol Eye Drops as Timolol may change effects of some medicines used during anaesthesia.

If your eye becomes irritated or any new eye problems comeon, talk to your doctor straight away. Eye problems could include redness of the eye or swelling of the eyelids (see Section 4: Possible Side Effects).

If you suspect that Timolol Eye Drops is causing an allergic reaction or hypersensitivity (for example, skin rash, or redness and itching of the eye), stop using these drops and contact your doctor immediately.

Tell your doctor if:

 you get an eye infection  you injure your eye or have an operation on it  your eye problems get worse or you get any new symptoms.

Use in children Timolol Eye Drops are not recommended for use in children and adolescents.

Using other medicines Timolol Eye Drops can affect or be affected by other medicines you are using, including other eye drops for the treatment of glaucoma. Tell your doctor if you are using or intend to use medicines to lower blood pressure, heart medicine or medicines to treat diabetes. Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without prescription.

It is important to tell your doctor before using Timolol Eye Drops if you are taking one or

more of the following medicines:

 a calcium antagonist, such as nifedipine, verapamil or diltiazem, often used to treat high blood pressure, angina, an abnormal heartbeat or Raynaud’s syndrome  digoxin, a medicine used to relieve heart failure or treat abnormal heartbeat  medicines known as catecholamine-depleting agents, such as rauwolfia alkaloids or reserpine, used for high blood pressure  medicines called pressor amines, such as adrenaline used to treat severe allergic reaction  Quinidine (used to treat heart conditions and some types of malaria)  Antidepressants known as fluoxetine and paroxetine.

 clonidine, a medicine used to treat high blood pressure  other beta-blockers taken by mouth or used as eye drops, because they belong to the same group of medicines as Timolol and could have an additive effect.

Pregnancy and breast-feeding Do not use Timolol Eye Drops if you are pregnant unless your doctor considers it necessary.

Do not use Timolol Eye Drops if you are breast-feeding. Timolol may get into your milk.

Ask your doctor for advice before taking any medicine during breast-feeding.

Driving and using machines There are possible side effects associated with Timolol Eye Drops, such as dizziness and changes in your eyesight, which may affect your ability to drive and/or operate machinery.

Do not drive and/or operate machinery until you feel well and your vision is clear.

–  –  –

Always use Timolol Eye Drops exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

The recommended dose is one drop in the affected eye(s) twice each day:

 one in the morning  one in the evening.

Do not change your usual dose without talking to your doctor.

Do not allow the tip of the container to touch the eye or areas around the eye. It may become contaminated with bacteria that can cause eye infection leading to serious damage of the eye, even loss of vision. To avoid possible contamination of the container, keep the tip of the container away from contact with any surface.

Instructions for use:

1. You must not use the bottle if the tamper-proof seal on the bottle neck is broken before you first use it. A gap between the bottle and the cap is normal for an unopened container.

2. Tear off the safety strip to break the seal.

3. To open the container, unscrew the cap by turning as indicated by the arrows.

4. Tilt your head back and pull your lower eyelid down slightly to form a pocket between your eyelid and your eye (see figure 2)

5. Invert the bottle and press lightly with the thumb or index finger over the "Finger Push Area" until a single drop is dispensed into the eye as directed by your doctor (see figure 3). DO NOT TOUCH YOUR EYE OR EYELID WITH THE DROPPER TIP

6. If dispensing is difficult after opening for the first time, replace the cap on the container and tighten (DO NOT OVERTIGHTEN) and then remove by turning the cap in the opposite direction as indicated by the arrows on top of the cap.

7. Repeat steps 4 and 5 with the other eye if instructed to do so by your doctor.

8. Replace the cap by turning until it is firmly touching the bottle. The arrow on the cap must line up with the arrow on the container for proper closure. Return the bottle to the original outer carton.

9. The dispenser tip is designed to provide a pre-measured drop; therefore, do NOT enlarge the hole of the dispenser tip.

10. After you have used all doses, there will be some eye drops solution left in the bottle.

You should not be concerned since an extra amount of solution has been added and you will get the full amount of Timolol that your doctor prescribed. Do not attempt to remove the excess medicine from the bottle.

Eye medications, if handled improperly, can become contaminated by common bacteria to cause infections. Serious damage to the eye and subsequent loss of vision may result from using contaminated eye medications. If you think your medication may be contaminated, or if you develop an eye infection, contact your doctor immediately.

Always use this medicine exactly as described in this leaflet or as your doctor, pharmacist or nurse have told you. Check with your doctor, pharmacist or nurse if you are not sure.

After using Timolol Eye drops, press a finger into the corner of your eye, by the nose (see figure 5) for 2 minutes. This helps to stop timolol getting into the rest of the body.

If you use more Timolol Eye Drops than you should

If you put too many drops in your eye or swallow any of the drops, you may:

 have a headache  feel dizzy or light-headed  have difficulty breathing  feel that your heart rate has slowed down.

If this happens, contact your doctor immediately.

If you forget to use Timolol Eye Drops It is important to take Timolol as prescribed by your doctor.

 If you miss a dose, use the drops as soon as possible.

 If it is almost time for the next dose, skip the missed dose and take the next dose at the usual time.

 Do not take a double dose to make up for the forgotten dose.

If you stop using Timolol Eye Drops If you want to stop using this medicine talk to your doctor first. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

4. Possible side effects Like all medicines Timolol Eye Drops can cause side effects, although not everybody gets them. If they do occur, you may need medical attention.

You can usually carry on taking the drops, unless the effects are serious. If you are worried, talk to your doctor or pharmacist. Do not stop using Timolol Eye drops without speaking to your doctor.

The frequency of possible side effects listed below is defined using the following convention Very common (affects more than 1 user in 10) Common (affects 1 to 10 users in 100) Uncommon (affects 1 to 10 users in 1,000) Rare (affects 1 to 10 users in 10,000) Not known (frequency cannot be estimated from the available data) If you experience the following, stop using Timolol Eye Drops and tell your doctor

immediately or go to the casualty department of your nearest hospital:

Allergic reactions, which may be severe and cause swelling of your face, tongue and throat resulting in difficulty breathing.

In some patients these may include:

The possible side effects relating to your heart are:

 a slower than normal heart rate  an abnormal heart rhythm  heart block (a problem with the electrical conduction system of your heart)  heart failure (symptoms of which can include shortness of breath)  palpitations  heart attack (symptoms of which can include severe chest pain)  worsening of angina and associated chest pain  swelling of parts of the body  worsening of pre-existing circulation problems  cold hands and feet

The possible side effects relating to your ears are:

–  –  –

The possible side effects relating to your eyes are:

 eye irritation including a feeling of burning and stinging in the eyes  inflammation of parts of your eyes or eyelids making them itchy, red, sticky or swollen  painful eyes or poorer than normal eyesight  loss of blinking reaction to objects near the eye  drooping eyelids  dry eyes  changes in vision including double vision  structural damage to the eye (possibly resulting in the appearance of flashes of light or ‘floaters’ in vision, or loss of vision) following eye surgery has also been reported if timolol was being used after the surgery.

The possible side effects relating to your digestive system are:

–  –  –

The possible side effects relating to your immune system are:

 itching  local or generalized rash  systemic lupus erythematosus (also known as “SLE” or “Lupus”), symptoms of which can include painful or swollen joints, muscle pain, unexplained fever or a red rash.

The possible side effects relating to your skin are:

 baldness  red, itchy, flaky rash or worsening of pre-existing psoriasis  itching  peeling of skin  purple-coloured spots and patches on the skin  sweating

The possible side effects relating to your metabolism are:

 higher than normal blood sugar levels (symptoms of which can include a great thirst, a dry mouth or the need to pass water often)  lower than normal blood sugar levels (symptoms of which can include feeling sick, sweating, weakness, faintness, confusion or coma).

The possible side effects relating to your nervous system are:

 stroke  dizziness  headache  fainting  a feeling of pins and needles  worsening of a disorder called myasthenia gravis which affects the muscles and causes weakness and tiredness.

The possible side effects relating to your brain are:

 depression  difficulty sleeping  an increased number of dreams  nightmares  memory loss  lack of concentration.

The possible side effects relating to your reproductive system are:

 a reduced sex drive  ‘Peyronie’s disease’ inmen, causing the penis to bend when erect  Impotence  Difficulty passing water

The possible side effects relating to your lungs are:

 difficulty breathing, particularly if you already have a disease affecting your lungs such as asthma. This may be serious enough to cause death  breathlessness  cough  fluid in the lungs  failure of the lungs to function normally (symptoms of which can include bluish skin, confusion or sleepiness).

The possible side effects relating to your circulatory system are:

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