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«Curriculum Vitae Prof. SAMIR K. BRAHMACHARI Director General, Council of Scientific and Industrial Research. Anusandhan Bhawan, 2, Rafi Marg, New ...»

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Curriculum Vitae

Prof. SAMIR K. BRAHMACHARI

Director General,

Council of Scientific and Industrial Research.

Anusandhan Bhawan, 2, Rafi Marg,

New Delhi-10001,INDIA

Phone: 91-11-2371 0472, 2371 7053

Fax : 91-11-2371 0618

Email : dgcsir@csir.res.in; skb@igib.res.in

Born: January, 1, 1952;

Nationality: Indian

Current position

Director General, Council of Scientific and Industrial Research, New Delhi,

Scientist and Founder Director, CSIR- Institute of Genomics and Integrative Biology, Delhi, Chief Mentor, Open Source Drug Discovery Unit, CSIR, New Delhi.

Academics 1972 Bachelor of Science in Chemistry (Hons), University of Calcutta.

1974 Master of Science in Chemistry (Specialisation, Physical Chemistry), University of Calcutta.

1978 PhD, Molecular Biophysics Unit, Indian Institute of Science, Bangalore.

1978-1979 Post Doctoral Research, French Govt. Fellowship, Institute de Recherche en Biologie Moleculaire, CNRS, University of Paris VIII.

1979-1981 Research Associate, Molecular Biophysics Unit, Indian Institute of Science, Bangalore.

1981-1997 Lecturer/ Assistant/Associate Professor, Molecular Biophysics Unit and Associated Faculty, Centre for Genetic Engineering, Indian Institute of Science, Bangalore.

1997-2001 Professor, Molecular Biophysics Unit, Indian Institute of Science, Bangalore.

1997-2007 Director, CSIR-Institute of Genomics and Integrative Biology, Delhi.

2003 Adjunct Professor, Bioinformatics Centre, University of Pune, Pune.

2007 Director General, Council of Scientific and Industrial Research (CSIR), New Delhi.

2013 Academy Professor, Academy of Scientific and Industrial Research (AcSIR), New Delhi Visiting Scientist Nov 1979 Dept of Biochemistry, Memorial University of Newfoundland, Canada.

June-Sept Department of Genetics and Development, Columbia University New York, USA.

1985 Visiting Professorship May-June 1997 Max Planck Institute of Biophysical Chemistry, Goettingen, Germany.

1998-2004 B.R Ambedkar Centre for Biomedical Research, University of Delhi, Delhi, India 2012 Joseph Austin McCartney & Ruth McCartney Hauck Named Visiting Professorship, Mayo Clinic, Rochester, USA 2013 Lifetime Honorary Professorship, Delhi University, India Honours & Awards 1968 National Science Talent Search Scholarship, NCERT India.

1979 Young scientist medal, Indian National Science Academy.

1981 Kani medal, National Cancer Research Centre, Tokyo, Japan.

1990 Shanti Swarup Bhatnagar Award in Biological Sciences, CSIR, India.

1 CV of Prof. Brahmachari 1998 C. R. Krishnamurthy Oration Award, Society of Biological Chemists, India.

1999 FICCI Award 1998-99 in recognition of individual initiative in Life Sciences including Agriculture, Federation of Indian Chambers of Commerce and Industry.

2000 Millennium Medal, Indian Science Congress.

Ranbaxy Research Award for the year 2001 in the field of “Medical Science – Medical 2002 Research”, Ranbaxy Science Foundation.

2003 Goyal Prize 2001; Life Sciences, Kurukshetra University.

2004 Prof. P.K. Bose Memorial Award, Indian Chemical Society.

2005 Dr. B.R. Ambedkar Centenary Award for Excellence in Biomedical Research, Indian Council of Medical Research.

2007 H. K. Firodia Awards For Excellence In Science and Technology, H.K. Firodia Memorial Foundation.

2007 Padma Bhushan Dr. R.A.Mashelkar Medal, Asian Paints.

2008 2005 VASVIK Award for Biological S&T, Vividhlaxi Audyogik Samshodhan Vikas Kendra.

2008 6th Biospectrum person of the year-2008, Biospectrum.

2008 Distinguished Alumni IISc, Alumni Association, Indian Institute of Science.

2009 SS Bhatnagar Memorial Award and Gold Medal, Indian Science Congress.

2009 The Jagadis Chandra Bose Medal 2007, Indian National Science Academy.

2009 2008 Shri Om Prakash Bhasin Award for S&T (Biotechnology), Shri O. P. B.Foundation for S&T.

2009 D.Sc. (Honoris causa), Vidyasagar University, India.

2010 D.Sc. (Honoris causa), Kalyani University, India.

2011 D.Sc. (Honoris causa), National Institute of Technology, Silchar, India.

2012 D.Sc. (Honoris causa), Amity University, Jaipur, India.

2012 J.C Bose Fellowship Award, DST, India 2013 Lifetime Honorary Professorship, Delhi University, India 2013 D.Sc. (Honoris causa), Bastar University, Jagdalpur (Chhatisgarh), India Fellowships / Membership of Academic Bodies 1991 Fellowship of the Indian Academy of Sciences.

1991 Elected member Human Genome Organization (HUGO).

1995 Fellowship of the Indian National Science Academy.

2000 Fellowship of the National Academy of Sciences.

2004-2011 Council Member, Human Genome Organization (HUGO).

2006 Advisory Board member for Archon-X prize for genomics, X-Prize foundation, USA.

2010 Fellowship of Indian National Academy of Engineering.

2010 Member, National Innovation Council, Government of India.

2012 Scientific Advisory Board Member of the U.S National Center for Biomedical Ontology (NCBO), Stanford University, USA.

–  –  –

2 CV of Prof. Brahmachari “Genome Research & Patenting in Developing Countries” in symposium on 2001 Bioethics, Vienna, Austria.

Rights & Issues relating to the “Genetic Resources of the Developing Countries”, 2002 Geneva.





Invited lecture in Bioscience Asia meeting on “Functional Genomics in Silico”, Taiwan.

2002 Lecture during the “India Day Celebrations” at Royal Society, London.

2002 “B. K. Bachhawat Oration”, Jawaharlal Nehru University, New Delhi, India.

2003 Invited talk entitled “Comparative Proteomics in silico for drug target identification”, 2004 th at 17 FAOBMB/IUBMB/A-IMBN Meeting, Bangkok, Thailand.

BIGROC Lecture “Conservation and Variation: A Balancing Act in the Genome”at 2005 Weizmann Institute of Science, Rehovot, Israel.

Invited lecture at the Asia Biotech Forum 2005 at Kuala Lumpur entitled “Private-Public 2005 Partnership in Genomics & Bioinformatics: An Indian Perspective”.

2005 Keynote address at the Workshop Health of Populations in the Mediterranean in the post genomic era entitled “Predictive Medicine and Health Research in the Post Genomic Era”, Tunisia.

Invited talk at the HGM 2005, entitled “Conservation and Variation: A Balancing Act 2005 in the Genome”, Kyoto, Japan.

th 2005 Invited talk at the 14 Conversation Albany, NY, USA.

2005 Invited talk entitled "Comparative Genomics and pathway modeling approaches towards Novel Drug Target Identification" at International Symposium on Computational Biology & Bioinformatics (ISCBB2005) in Tokyo, Japan.

2006 Invited talk at the session Genomics in Asia during the 2006 International Conference on Genomics entitled “Genome Variation & Disease Genomics: the Indian Initiative”, Hangzhou, China.

“Indian Genome Variation Database from Complex Disease Perspective” at 2007 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore.

Invited talk at the Genesis Conference in London entitled “Can Open Source Drug 2008 Discovery Address Global Healthcare Challenges in Infectious Diseases?”.

“Open Innovation: A Novel Approach to Collaborative Research for Global Good” 2009 at Swedish parliament.

“Technology Based Applications for Development for the Benefit of the Masses, 2010 Perspective of Government of India” at Washington DC, USA.

“Knowledge Creation and Open Innovation for Global Good” at ASET Colloquium, 2010 TIFR, Mumbai, India.

“Human Genome Variome and Predictive Medicine: Hope & Reality” on the occasion 2008 of the Foundation Day of Institute of Life Sciences, Hyderabad, India.

Keynote address: “Genome Sequencing to Drug Discovery: An Open Innovation 2010 Model for Global Collaboration” at the HUGO-OECD Symposium on Genomics and Bio-economy, France.

Plenary talk on “Open Source Drug Discovery: A Solution for Infectious Diseases” 2010 at the International Conference on Bioinformatics of Genome Regulation and Structure, Novosibirsk, Russia.

“Tale of Three Cities: A Molecular Journey”, at Indian Chemical Society.

2010 “ Preparing for Leadership of Tomorrow” a Convocation Address at North Bengal 2010 University. India “Positioning for Success: Leveraging the Power of Dreams, Commitment and 2010 Perseverance” a Convocation Address at NIPER-Kolkata.India “Open Source Drug Discovery: A New Paradigm” at TEDx.

2010 http://tedxncr.com/speakers.html “Intellectual Property Protection vs. Investors Property Protection”, Confederation 2010 of Indian Industry.

“Open Innovation: A Novel Approach to Collaborative Research for Global Good” 2011 th on 15 Prof. Y. Nayudamma Memorial Award Lecture at Chennai.

BigRoc lecture entitled “Open Source Drug Discovery”, Weizmann Institute of Science, 2011 Rehovot, Israel.

–  –  –

Editorial Work/International Responsibilities (Selected List)  Regional Editor (South Asian Countries) Journal Genomic Medicine, 2006 onwards.

 Council editor, The HUGO Journal, 2010-Present.

 PLoS ONE Academic Editor 2008 - 2010.

 Member of the Board of Advisors of Journal of Biomolecular Structure and Dynamics (JBSD), 2010.

 Member, FAOBMB council, 1995-2004.

 Member of India-European Commission S&T Steering Committee responsible for Genomics & Biotechnology for Health 2003-2007.

 Member, Planning Group of the Human Variome Project Melbourne, Australia, 2006.

 Chairman, 13 International Human Genome Meeting (HUGO), 2008, India.

th  Member and Area Coordinator, INDO-RUSSIA ILTP Joint Council, 2003 – Present.

 Member of the international Advisory Panel on Biotechnology Development (BIO-IAP) of Malaysia for the period 2009-2011.

 Section Editor of Medical Bioinformatics Section of Journal of Translational Medicine, 2012- till date.

4 CV of Prof. Brahmachari Achievements in Scientific Research Prof. Brahmachari, recognized as distinguished alumni from the school of Molecular Biophysics at Indian Institute of Science, received his early training in structural biology of proteins and polypeptides. He has more than 12 patents, 23 copyrights and 150 research publications to his credit. He has made outstanding contributions in understanding the role of repetitive DNA in genome function in health and disease. He visualized the integration of structural biology with genomics, molecular biology and information science forging towards integrative biology. Prof. Brahmachari made fundamental discoveries in demonstrating the structural flexibility of DNA and the role of repetitive sequences in DNA transactions much before the discovery of repeats association with genetic basis of several neurological disorders. His work on the structural flexibility of telomeric repeat sequences is one of his well cited pioneering contributions, which has led others to develop approaches for cancer therapeutics. He sought to understand the functional relevance of repetitive DNA in clinical context that resulted in extensive collaboration with a large number of clinicians and also in motivating young physicians to undertake research in genomic sciences. Through a combination of directed research, he seeded functional genomics research in India, moving away from the prestigious Indian Institute of Science, Bangalore, to found the CSIR- Institute of Genomics and Integrative Biology in Delhi.

Prof. Brahmachari has made major contributions in molecular analysis of genetic disorders associated with trinucleotide amplification and repetitive sequence instability. Using a combination of structural biology, computational genomics and population based polymorphism scanning, he and his group have provided a novel structural frame work for understanding the etiology of several neurological disorders. One of the outcomes of these efforts has been the demonstration that loss of triplet repeat interruption as the primary steps in ataxia SCA 2 which is followed by repeat expansion. In addition, he has made major contribution in identifying founder chromosomes of several Spino Cerebellar Ataxia and Huntington’s Disease in India.

Repeat polymorphism in the genome and variation in coding sequences reflected in these diseases brought an insight into the balancing act of nature between variation and conservation. This eventually led to his conceptualization and execution of the Indian Genome Variation project.

Prof. Brahmachari has established the CSIR Indian Genome Variation Consortium Project for predictive and personalized medicine with a team of 150 researchers including scientists and students to provide the first comprehensive genetic map of the extremely diverse Indian population with different evolutionary history, comprising thousands of endogamous populations and hundreds of functioning languages. The execution of the project was strategically planned with the development of innovative cost-effective methods and suitable private-public partnerships. A major discovery has been that despite enormous diversity, the populations of India could cluster into 5 major groups. This has been enormously 5 CV of Prof. Brahmachari useful in designing a large number of studies that aim to identify predictive markers for complex diseases and pharmacogenomics studies. The basal data has also been useful in tracing migration history of populations; the most striking has been the sampling of Asian populations, identifying risk haplotype for carrier detection and also discovering signatures of selection for as in the case of high altitude adaptation.

Under his leadership, the Institute (CSIR-IGIB) rose to the forefront of clinical genomics in India, addressing nationally important problems such as identifying risk markers for pulmonary edema in soldiers posted at high altitudes. In many diseases of relevance to the Indian people, such as asthma, diabetes, cardiovascular disease, and schizophrenia, he master-minded the development of translational research programs in concert with clinical institutions. This set the stage for inter-institutional collaborative research, which had been largely missing before.

Prof. Brahmachari leveraged the angle of personalised medicine towards pharmacogenomics with focus on affordable healthcare.



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