«Dr. Aaron James Wyman Business Address: Assistant Professor of Biology 108C Whiteman-Gibbs Department of Biology 106 E Main St Spring Arbor ...»
Dr. Aaron James Wyman
Assistant Professor of Biology
Department of Biology
106 E Main St
Spring Arbor University
Spring Arbor MI 49283
April 1997 B.S. in Biochemistry with Honors, ACS certified, Cum Laude
Alma College (Alma, MI 48801)
May 1999 M.S. in Biology, University of North Carolina-Chapel Hill
Advisor: Professor Ralph S. Quatrano December 2004 Ph.D. in Molecular, Cellular, & Developmental Biology Dissertation: “Analysis of the Heat Stability, Folding Dynamics, and Structure of the Manganese Stabilizing Protein of Photosystem II” University of Michigan-Ann Arbor Advisor: Professor Charles F. Yocum Honors and Achievements 1999 Student Undergraduate Teaching Award, University of North Carolina-CH 1999 Member of the Academy of Distinguished Teaching Scholars, University of North Carolina-CH 2002-2003 Pfizer Dissertation Research Grant 2007 Recipient of American Society of Plant Biologists Travel Grant 2007 Recipient of New Investigator Award, Ninth International Conference on the Chemistry and Biology of Mineralized Tissues 2009 Recipient of American Society of Plant Biologists Travel Grant 2013 Recipient of Spring Arbor University McKenna Scholars Award 2015 Recipient of Spring Arbor University Faculty Merit Award Aaron Wyman Professional Activities 1997-2009 Member, American Chemical Society (Biological Chemistry Division) 2001-Present Member, American Society of Plant Biologists (Midwestern Section) 2014 – 2015 American Society of Plant Biologists Midwestern Section Vice-Chair 2015 – 2016 American Society of Plant Biologists Midwestern Section Chair 2011-2012 Member, Council on Undergraduate Research 2011-2012 Member, Illinois State Academy of Science Attended the following workshops provided by the Center for Research on Learning and
Teaching, University of Michigan-AA, including:
Active Learning: A Special Workshop for Continued Biology GSI Training Learning the Sciences: Moving Active Learning from the Lab to the Lecture Observing Classes and Collecting Midterm Student Feedback Getting Ready for an Academic Career: Preparing Future Faculty (PFF) Conference Life after the Ph.D.: Adjusting to a New Institutional Context Attended the following workshop offered by the Sweetland Writing Center, University of
Writing Assignments in Biology: Tips for Creating Useful Assignments and Strategies of Efficient Grading Attended the 2011 Lab Leadership Workshop sponsored by the American Society of Plant Biology Research and Professional Experience 2004-2005 Post-Doctoral Research Associate, Dept. of Biochemistry, Purdue University Advisor: Professor Joe Ogas 2005-2006 Visiting Assistant Professor of Biochemistry (Chemistry Department), Wabash College (Crawfordsville, IN 47933) 2006-2008 Post-Doctoral Research Associate, Dept. of Botany & Plant Pathology, Purdue University Advisor: Professor Mary Alice Webb 2008-2012 Assistant Professor of Biology, Aurora University (Aurora IL 60506) 2011 Visiting Research Professor, Molecular, Cellular, & Developmental Biology, University of Michigan-Ann Arbor 2012-Present Assistant Professor of Biology, Spring Arbor University (Spring Arbor MI 49283)
2001-2004 Graduate Student Teaching Mentor (University of Michigan-AA):
BIO 801 Biology Graduate Student Instructors Training (6 terms)
Membership and Service to University Government and Organizations 2009 - 2012 Early Academic Intervention (EAI) Group (Aurora University) 2010 – 2012 Reformation of General Education Program Model Group (Aurora University) 2010 – 2011 Co-founded and mentored AU Health Science Club (Aurora University) 2011 – 2012 College of Arts and Sciences Curriculum Committee (Aurora University) 2012 – 2014 Career Development Faculty Advisory Board (Spring Arbor University) 2013 – Present School of Arts and Sciences Faculty Development Committee (Spring Arbor University) 2015 – Present McKenna Grant Committee (Spring Arbor University) Mentorship of graduate and *undergraduate laboratory research projects 2005 Michelle Drennan: “Determination of Potential Interactors of a Plant CHD3 protein.” 2005 *Megan M. O'Shaughnessey: “Characterization of PKL and other Chromatin Remodeling Factors Involved in Regulation of Chromatin in Arabidopsis thaliana.” 2005 *Yoshiaki Hagiwara: “Identification of Chromatin-Remodeling Factors that Contribute to Repression of PKL-Dependent Genes.” 2006 *John P. M. Manolo: “Isolating and Identifying Novel RAPs.” 2006 *Shane G. Dixon: “Isolation and Characterization of Proteins Associated with Calcium Oxalate Crystals.” 2006 *Ahson Ali: “Analysis of Factors Influencing the Nucleation, Growth, and Morphology of Calcium Oxalate Crystals.” 2006 *Sheryl A. Walker: “Genetic and Biochemical Characterization of Plant RaphideAssociating Proteins.” 2007 *Carrie A. Anderson: “Cloning and Expression of Plant Raphide-Associating Proteins.” 2007-08 *Carrie A. Anderson: “Cloning, Expression, and Analyses of Plant Oxalate Transporters.” 2007 *Davide W. Marzoli: “Isolation and Identification of Calcium Oxalate-Associated Proteins in Vitis labrusca.” 2007 *Jessica R. Driesenga & *Carrie A. Anderson: “Investigations of Ion Accumulation within Plant Cells.” 2008 *Sheryl A. Walker: “Genetic Characterization of Anion Transporters in Arabidopsis thaliana.” 2009 *Helena Triantafillou: “Effects of Nutrition on Bombyx mori Growth and Development.” 2010 *Dehlia Albrecht: “Genetic Characterization of Anion Transporters in Arabidopsis thaliana.”
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2010 Jessica Tartaglione: “Investigations of Ion Accumulation within Plant Cells.” 2010 *Phillip Van Dyke: “Analysis of Biological Factors Influencing Biomineralization.” – Honorable mention 2010 ASPB SURF *Samantha Wild: “Genetic Characterization of Putative Calcium Modulators in 2010-2012 Arabidopsis thaliana.” *Jessica Nichols: “Molecular Analyses of Potential Calcium Biomineralization 2010-2012 Factors.” – Recipient of 2011 Harvey A. Friedman Center for Aging REA, Washington University; PhD student in Department of Biomedical Sciences at University of AlabamaBirmingham *Aaron Downing: “Cellular and Molecular Analyses of Plant-based HINTs.” 2011-2012 *Brock Koppleman: “Analysis of the Properties of Flame-Gel.” 2010-2013 2012 - 2014 *Alyssa Castle: “Cellular, Genetic, and Molecular Studies of Plant-Based HINT’s.” – Recipient of 2014 Interdisciplinary REU Program in the Structure and Function of Proteins, UM – AA School of Pharmacy 2013 *Doug Minier: “A Potential Biological Control of the Invasive Shrub Frangula ulnus.” MS student in Department of Plant Pathology at Michigan State University 2013-Present *Karen Chanchavac: “Cellular, Genetic, and Molecular Studies of Putative Plant Peroxisomal Proteins.” – Honorable mention 2014 ASPB SURF; Recipient of 2015 REU Program in Plant Genomics Michigan State University *Salvatore Meleca: “Chemical Characterization of Metabolic Processes in 2013-2014 Alcanivorax borkumensis” New York College of Podiatric Medicine 2014 *Autumn Freeman: “Investigations of Technology to Improve Comprehension and Retention of Scientific Concepts for Auditory, Visual, and Kinesthetic Learners.” 2014 *Sarah Gibson: “Impact of Salicylate on Microbial Motility, Flagella Production, and Gene Expression.” Palmer College of Chiropratic 2015 - Present *Sienna Lopez: “Exploring Genes and Their Products for Novel Impacts on Plant Growth and Development.” – Recipient of 2015 ASPB SURF Fellowship 2015 *Hannah Schroeder: “Prokaryotic Gene Expression Analysis in the Presence of Various Inhibitors.” 2015 *Josie Nieboer : “Cellular and Molecular Investigations of Biomedically-relevant Microbes.” 2015 *Samantha Luce: “The Impact of Salicylate Treatments on the Motility and Cellular Characteristics of Proteus and Pseudomonas Species.” Mentorship of graduate and *undergraduate writing research projects 2009 *Phillip Van Dyke: “Analysis of DNA Sequences Involved in Biomineralization.” 2009 *Valerie Mazzone: “A Clear View of Alzheimer’s” 2009 *Jessica Tartaglione: “Effects of Morphine on the Nervous System.”
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2011 *Kariann Lazansky: “Examination of the Impact of Reservatrol on Aging.” 2012 *Samantha Dykema: “Investigations into the Cellular and Molecular Characteristics of Antibiotic-resistant Enterobacteriaceae.” 2012 *Natalie Jansen: “Characterization of the Cellular, Molecular, and Biochemical Impacts of Common Variable Immune Deficiency (CVID).” PhD student in Medical Sociology at the University of Kansas 2012 *Ricardo Dominguez: “Inquires into Nanotechnology: Artificial and Replacement Tissues and Organs.” 2014 *Seth Tippin: “Investigations of the Scientific, Ethical, and Society Impacts of Transgenic vs. Conventional Breeding of Photosynthetic Foodcrops.” Research Experience January 1998-May 1999: Masters of Science research in the laboratory of Dr. Ralph Quatrano (Department of Biology, University of North Carolina-Chapel Hill); Using cellular, genetic, and molecular biological techniques, I screened a Fucus distichus (brown alga) cDNA library isolated from Fucus embryos at a specific developmental stage for transcripts encoding proteins containing signal sequences allowing for targeting to the cell membrane. Transcripts carrying membrane signal sequences and encoding proteins potentially involved in mediating asymmetric cell division and development were identified and isolated.
March 2000-October 2004: Ph.D. dissertation research in the laboratory of Dr. Charles Yocum (Department of Molecular, Cellular, & Development Biology, University of Michigan-Ann Arbor); I analyzed the structure and function of the manganese stabilizing protein of Photosystem II, using a variety of molecular biological, biochemical, and biophysical techniques, to better elucidate how this protein’s “intrinsically disordered” structure enables it to assist in the maintenance of the enzyme complex’s manganese cluster (the catalytic site of water oxidation).
November 2004-May 2005; post-doctoral research associate in the laboratory of Dr. Joseph Ogas (Department of Biochemistry, Purdue University); In this work, I studied the effects of mutating genes involved in both plant hormone production and response, and genes encoding for chromatin remodeling factors, on plant growth and development using genetic, molecular biological, and biochemical techniques.
July 2005-present; in collaboration with Dr. Mary Alice Webb (Department of Botany & Plant Pathology, Purdue University), I and numerous undergraduate research students have investigated the mobilization, transport, and storage of ions, including calcium and the antinutrient oxalate, composing biominerals in plants and animals. This work has also included identifying, isolating, and characterizing genes and their encoded polypeptides potentially involved in the nucleation, growth, and morphology of calcium-based crystals in plants and calcium oxalate stones in insect kidney-like organs. This work has involved use of techniques from genetics, cellular and molecular biology, and biochemistry and has been incorporated into my undergraduate teaching and research labs.
June 2011-present: in collaboration with Dr. Laura Olsen (Department of Molecular, Cellular, and Developmental Biology, University of Michigan-Ann Arbor) and numerous undergraduate researchers, I’ve undertaken research projects analyzing the generation and function of peroxisomes, small, uni-membraned organelles present in all eukaryotic cells. Peroxisomes
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serve diverse roles, including regulating stress responses, photorespiration, plant hormone synthesis and processing, and lipid metabolism. These studies have focused on nuclear genes in plants whose encoded products must be targeted and transported to the organelle by signal sequences and processes that are not fully characterized. This works lends itself to genetic, cellular, molecular, and biochemical approaches that are being translated to undergraduate lecture and lab settings.
June 2015-present: in collaboration with Dr. Lyle Simmons (Department of Molecular, Cellular, and Developmental Biology, University of Michigan-Ann Arbor) and numerous undergraduate researchers, I am analyzing the impact of changes on Bacillus subtilis genome content on its physiology and function. This works lends itself to genetic, cellular, molecular, and biochemical approaches that are being translated to undergraduate lecture and lab settings.
Publications (* involved undergraduate authors) Wyman, A. J., Popelkova, H., and Yocum, C. F. Site-Directed Mutagenesis of Conserved CTerminal Tyrosine and Tryptophan Residues of PsbO, the Photosystem II Manganese Stabilizing Protein, Alters Its Activity and Fluorescence Properties. Biochemistry 47(24): 6490-8, 2008.
Wyman, A.J. and Webb, M.A. Calcium Oxalate Accumulation in Malpighian tubules of Silkworm (Bombyx mori). In: Renal Stone Disease: Proceedings of the First International Urolithiasis Research Symposium. A.P. Evan, J.E. Lingeman, and J.C. Williams, eds. American Institute of Physics, Melville, NY., 407-411, 2007.
Wyman, A. J. and Yocum, C. F. Function of the Disulfide Bond of the Photosystem II Manganese Stabilizing Protein. Photo. Res. 85: 359-372, 2005.
Wyman, A. J. and Yocum, C. F. Assembly and Function of the Photosystem II Manganese Stabilizing Protein: Lessons from its Natively Unfolded Behavior. Photo. Res. 84: 283-288, 2005.
Wyman, A. J. and Yocum, C. F. Characterization of the Thermodynamic Properties of the Natively Unfolded Manganese Stabilizing Protein of Photosystem II. Proceedings of the 13th International Photosynthesis Congress, Montreal, Canada (van der Est, A. and Bruce, D., Eds.), Allen Press, Lawrence KS 1: 248-250, 2004.
*Beckmann, J. D., Burkett, R. J., Sharpe, M., Giannunzio, L., Johnston, D., Abbey, S., Wyman, A., and Sung, L. Spectrofluorimetric Analysis of 7-hydroxycoumarin Binding to Bovine Phenol Sulfotransferase. Biochim. Biophys. Acta 1648: 134-139, 2003.
*Belanger, K. D., Wyman, A. J., Sudol, M. N., Singla-Pareek, S. L., and Quatrano, R. S. A Signal Peptide Secretion Screen in Fucus distichus Embryos Reveals Expression of Glucanase, EGF Domain-containing, and LRR Receptor Kinase-like Polypeptides during Asymmetric Cell Growth. Planta 217: 931-950, 2003.